The serum cys c has important diagnostic value in early stage of diabetic nephropathy group.
血清cys c在早期糖尿病肾病中有较高的检出率，对早期糖尿病肾病的诊断具有重要价值。
Objective To study the relationship between the serum Cys C level and the prognosis of patients admitted to intensive care unit.
目的 探讨急诊危重病患者血清胱抑素C浓度的改变与预后的关系。
Results The Cys C level in the survival group was significantly lower than that in the dead group.
结果 存活组Cys C浓度与死亡组Cys C浓度比较差异有统计学意义。
In all kinds of human essential amino acids, the first limiting amino acid was Met + Cys.
在各种人体必需氨基酸中，第一限制氨基酸为蛋氨酸＋胱氨酸。
The proposed method had been used in the determination of GSH or Cys in biological samples and obtained satisfying results.
利用本法测定了人全血中，猪的肝脏和心脏中的GSH及人尿样中的Cys，结果令人满意。
Mol l〓 for Cys and 1.49×10〓mol l〓 for GSH, respectively.
Cys和GSH的检出限（S／N=3）分别为2.36×10〓mol l〓和1.49×10〓mol l〓。
Our results not only reveal the fundamental basis for the mechanistic detail of Cys nitrosylation of PTPs, but offer insights into a novel biological role of NO that may govern tyrosine phosphorylation-dependent signaling through regulation of cellular PTPs.
综合本研究的结果，不只显示了PTPs 半胱胺酸亚硝基化作用重要的基本分子机制，并且证实了一氧化氮藉由亚硝基化作用影响PTPs活性而扮演重要细胞生理调控的角色。
Molecular Orbital Theory and Crystal Field Theory demonstrated the possibility of the complextion reaction between L-Cys and hemoglobin.
运用分子轨道杂化理论和配合物晶体场理论论证了半胱氨酸和血红蛋白之间发生配位反应的可能性。
Cys10 is proven to be responsible for its rapid radical scavenging function and tyrosines take part in the binding of antioxidin-RL to radicals according to our nuclear magnetic resonance assay.
为进一步研究和开发利用抗氧化多肽antioxidin-RL在生物医学、抗氧化保护以及化妆品研发等方面的价值提供了理论基础。
Methods:We compared the performances of 14 Scr and 9 Cys C estimated GFR equations using inulin clearance as the reference test in 103 stable renal transplant populations.
我们收集了103名肾移植患者的数据，比较了14 Scr 和9Cys CGFR计算公式，采用菊粉清楚率作为对照。
2Cys-and 3Cys- containing peptides were selected for test on a PEGA resin with an uncleavable thiol linker.
通过对含有2Cys和3Cys的环肽的合成来检验在带有不可裂解的linker的PEGA树脂上的环合反应。
Students with a senior together, I used the electronic spin resonance technology and computer-assisted methods, Cys421 residues in the preparation of a spin label MSL enzyme, Copper ions to measure the distance and spin labeling.
与一个大四的同学一起，我用电子旋转共振技术以及电脑辅助方法，在Cys421残留物中准备了一MSL旋转标签的酶，衡量了铜离子与旋转标签的距离。
The BLV molecules make hydrogen bonds and hydrophobic interactions with PKC, which are similar to those in the crystal structure of the cys2 domain of PKC in complex with phorbol 13-acetate.
四个BLV分子与PKCd形成氢键和疏水作用，这些作用与PKCd和佛波13-酯的复合物中的相互作用相似。
Second, residues in the reactive site of the inhibitor were replaced by the consensus substrate recognition sequence of furin, namely, Arg at P_1, Lys at P_2, Arg at P_4 and Arg at P_6. In addition, the P_7 residue Asp was substituted with Ala to avoid possible electrostatic interference with furin inhibition. Finally, the extra N and C terminal residues beyond the doubly conjugated disulfide loops were further truncated. However, all resultant synthetic peptides were found to be temporary inhibitors of furin and kexin during a prolonged incubation, with the scissile peptide bond between P1 and P`1 cleaved to different extents by the enzymes.
高活性、低分子量的furin酶抑制剂有可能发展成为新型的抗细菌内毒素和抗病毒感染的药物，我们以绿豆胰蛋白酶抑制剂Lys片段长链22肽为模板，设计了一系列能抑制furin和kexin活性的突变体，采用如下三种方法逐步优化：一、去除Lys片段长链三对二硫键中的一对，用Ser替换Cys，减少可能存在的二硫键错误配对；二、抑制剂的活性中心根据furin底物的专一性逐步改变，即P1、P2、P4和P6位分别变为Arg、Lys、Arg和Arg，同时为了避免P7 Asp和P6 Arg之间可能存在的相互作用，将P7位Asp替换为Ala；三、将两对二硫键形成的双环的外面5个氨基酸残基去除。
Abstract］ dopuin/cox17p is a new bioactive peptide which has been demonstrated in yeast and porcine intestine recently. they are about 8057 da which consist of 62-residue. according to swiss-prot, they also exist in plasmodium, anopheles, drosophila, king cobra and shark. cdna sequence of mouse and human are homologous. though their primary structure are different with their species, they all have rich proline exists in n-terminal and 6-cys locates in 22, 23, 25, 35, 44 and 54.three intrachain disulphide bonds have been found in porcine intestine peptide. they locates in the membrane of mitochondria in yeast. when they go out to cell membrane they capture cu+, and now are accepted as a new member of polyoxidoreductase. they take part in the electron transformation and the reduction of oxygen to water. also, they act as hormone in nerve and endocrine system. this article summarizes the expression and the function of dopuin/cox17p in creatures. we think that it's necessary to develop their relative drugs, because they take high interaction with the enzyme's activation of energy metabolisming and human disease of copper absent.
dopuin/cox17p是新近从酵母和猪小肠中发现和鉴定的一种生物活性肽，分子量8057 d左右，加工成熟的活性形式由62个氨基酸残基组成。从dna和蛋白质数据库中发现，动物中的疟原虫、疟蚊、果蝇和鲨、蛇，以及植物中的拟南芥均存在对应肽，鼠和人的cdna库中也有对应序列。尽管因种属不同在一级结构上略有差异，但其n端脯氨酸密集，22、23、25、35、44和54位点为6个半胱氨酸，从猪小肠纯化肽的3对链内二硫桥键已定位。在酵母中，此肽主要分布于线粒体内膜，捕获细胞膜上的cu+，为氧化还原复合多酶体系成员，在呼吸链末端传递电子将o2还原为h2o。同时，它在内分泌系统中起着激素的作用。现将dopuin/cox17p肽的生理功能及其基因表达调节方面的有关研究进行综述如下。此肽与机体能量代谢的酶活性相关，有重要理论和临床研究价值。
Methods: By using the fusion protein expression protocol with unique acid labile linker Asp-Pro, the Pro-hGHRH(1-44)-Gly-Gly-Cys peptide was obtained.
通过使用独特的酸敏感水解位点Asp-Pro的原核表达系统，构建了新的Pro-hGHRH(1-44)-Gly-Gly-Cys类似肽。
Methods: A 135 Cys to Tyr point mutation p53-transduced P815 mastocytoma (P815-mp53) was used as an experimental tumor and the p53 protein as the model of tumor associated antigen. rVV-p53M and rVV-B7 were used as vaccine to test their induction of CTL and antitumor immunity.
选择人135位Cys→Tyr点突变p53为肿瘤相关抗原模型，观察包含该点突变p53抗原肽p53125～145的重组痘苗病毒rVV-p53M单独和联合应用表达B7的重组痘苗病毒rVV-B7诱导的CTL及对荷瘤小鼠的免疫保护和治疗效应。
Methods: A 135 Cys to Tyr point mutation p53 transduced P815 mastocytoma (P815-mp53) was used as an experimental tumor and the p53 protein as the model of tumor associated antigen. rVV-p53 and rVV-B7 were used as vaccine to test their induction of CTL and antitumor immunity.
选择人135位Cys→Tyr点突变p53为肿瘤相关抗原模型，观察包含该点突变p53抗原肽p53125~145的重组痘苗病毒Rvv-p53单独和联合应用表达B7的重组痘苗病毒rVV-B7诱导的CTL及对荷瘤小鼠的免疫保护和治疗效应。
P53M. Methods P815 mastocytoma transduced with a 135 Cys to Tyr point mutation p53 was used as an experimental tumor P815?
方法以人135位Cys→Tyr点突变p53为肿瘤相关抗原模型，观察以表达该点突变p53蛋白的重组痘苗病毒rVV？
objective to evaluate the quality diagnositic value of3d-ffe thin thickness enhancement scanning in brain cysticercosis. methods according to238brain cysticercosis patients conventional sequence scanning（t 1 wi/se, t 2 wi/tse, flair and t 1 wi/se enhancement scanning）and3d-ffe thin slice enhancement scan-ning, compare to t 1 wi/se enhancement scanning and3d-ffe thin slice enhancement scanning, the signal to noise ratio, grey-to-white contrast-to-noise ratio, and detection ratio of lesions were measured. the results were compared with the two sequences. results snr of the3d-ffe thin slice enhancement scanning is higher than t 1 wi/se enhancement scanning. the g-w cnr of3d-ffe thin slice enhancement scanningwas low-er than that of t 1 wi/se enhancement canning.3d-ffe thin slice enhancement scanning showed higher detection rate than t 1 wi/se enhancement scanning. conclusion 3d-ffe thin slice enhancement scanning has better lesion contrast. it can improve the detection of the brain cysticercosis and quality diagnositic rate, so it may be as brain cys-ticercosis conventional sequence.
目的 评价3d-ffe薄层增强扫描在脑囊虫病定性诊断中的意义。方法通过对238例脑囊虫病患者常规序列扫描（即t 1 wi/se、t 2 wi/tse、flair、t 1 wi/se增强扫描）及3dffe薄层双倍量增强扫描，比较t 1 wi/se增强扫描及3dffe薄层增强扫描图像的信躁比，病变与脑灰质的对比噪声比及病灶的对比噪声比以及病变检出率、头节检出率进行对比。结果 3dffe/t 1 wi薄层增强扫描的snr高于t 1 wi/se增强扫描，脑灰白质对比噪声比低于t 1 wi/se增强扫描，对于病变的检出、头节检出及多环征的检出，3d-ffe/t 1 wi薄层增强扫描明显高于t 1 wi/se增强扫描。结论 3d-ffe薄层增强扫描，能大大提高囊虫检出率及定性诊断率，可作为脑囊虫病检查的常规序列。