Interleukin is an important inflammatory monocytic factor acting to multiple target cells.
白细胞介素是其中较为重要的能作用于多种靶细胞的炎症性单核细胞因子。
Third partThe expression of HO-1 could inhibit the invasion of inflammatory cells, activation of transcription factor AP-1 and the production of cytokines, also could improve the oxdative stress state of the VILI and lessen the lung injury.
第三部分HO-1的表达增高能够抑制炎症细胞浸润、转录因子AP-1活化和细胞因子的产生，同时改善肺内氧化应激状态，可能是HO-1对VILI发挥保护作用的机制。
Objective To determine levels of nonspecific inflammatory factor and IMT in different glycometabolism stages and to study the relationship between the inflammatory reaction and diabetes and atherosclerosis.
目的 通过观察不同糖代谢阶段患者非特异性炎性标志物水平以及颈动脉内膜中层厚度，研究炎症反应与糖尿病及动脉粥样硬化的相互关系。
Methods:A rabbit model was developed with scald complicated with artificial infection of Pseudomonas aeruginosa. Studies were carried out by using the combat trauma spray group and the solution group. At day1, 2, 4, 7, 14, post experiments, rabbit serum was collected, the body temperatures of animals were taken, and such inflammatory factors as white cell count, serum levels of NO 2-/NO 3-, serum levels of tumor necrosis factor, serum superoxide anion, as well as GPT, AKP, aspartate carbamyl transferase, urea nitrogen were also collected to measure the functions of both the kidney and liver.
采用烫伤合并人工感染绿脓杆菌的家兔模型，用战伤喷剂与溶剂组于实验前和实验后第1、2、4、7、14天采集家兔血清，测量体温，检测白细胞数、血清NO 2-/NO 3-水平、血清肿瘤坏死因子水平、血清超氧阴离子等炎性因子水平以及谷丙转氨酶、碱性磷酸酶、天冬氨酸转移酶、肌苷和尿素氮等肝肾功能指标水平。
Pneumoniae or challenged with the pneumococcal virulence factor pneumolysin, and inflammatory leukocyte recruitment, bacterial pathogen elimination, and resolution/repair processes were determined.
用肺炎球菌感染或者用肺炎球菌致病因子pneumolysin刺激PI3K敲除鼠和野生型鼠，检测炎症导致的白细胞募集、病原体的清除、以及修复过程。
An exaggerated inflammatory response has been proposed to be one etiological factor.
过度的炎症反应被认为是其病因之一。
It has been reported that endotoxin-induced generations of inflammatory mediators, such as prostaglandins and tumor necrosis factor, are reduced in this endotoxin tolerance model.
已有报道，在这种内毒素耐受大鼠，由内毒素引起的炎症介质，如前列腺素和肿瘤坏死因子，均明显减少。
This review briefed the relation between apoptosis and acute pancreatitis, investigated the influence of apoptosis on acute pancreatitic organ damage, and analyzed the relation between apoptosis and inflammatory cytokines, oxidative stress, endoplasmic reticulum stress, Notch factor, aiming at revealing the mechanism of apoptosis in acute pancreatitis.
本文简述细胞凋亡与急性胰腺炎之间的关系，探讨细胞凋亡对急性胰腺炎器官损伤的影响，分析细胞凋亡与炎症因子、氧化应激、内质网应激、Notch因子的关系，从而揭示急性胰腺炎细胞凋亡的发生机制。
Interleukin-8 (IL-8) is the first chemotactic factor identified by Yoshimura in 1987. It can activate and chemotact neutrophils, playing critical roles in inflammatory responses of many disease.
白细胞介素-8(interleukin-8，IL-8)是1987年Yoshimura发现的第一个趋化因子，它可以激活和趋化嗜中性粒细胞，在许多疾病的炎症反应中发挥重要作用。
IL-8 is a powerful neutrophil chemotactic factor, and it is related with the inflammatory reaction. IL-8 expression levels may be related to the certain type of syndrome.8.IL-8 protein and mRNA expression of Hp-positive group had the higher tendency than that of Hp-negative group.
IL-8为一强大的中性粒细胞趋化因子，与炎症反应关系密切，IL-8的表达水平可能与证型存在着一定的相关性。8、IL-8蛋白和mRNA表达水平呈现Hp感染组较非Hp感染组偏高的趋势。
It is reported that nuclear factor-κB plays an important role during the course of CGN. NF-κB can specially bind to theκB binding sites which lie in the promoter or enhancer of many genes, and participate in some transcriptional control of genes relevant to immunological and inflammatory reaction.
其中，核转录因子-κB能与多种基因的启动子和增强子中的κB序列位点特异结合，参与多种与免疫和炎症反应有关的基因转录调控，在慢性肾炎的发病过程中发挥着至关重要的作用。
PAF can not only induce PMN to pro- duce chemotaxis, adherence, aggregation, degranulation, phago- cytosis, respiratory burst and superoxide free radicals production, but also inflammatory factor releases, including IL--8、TNF--α、〓、PAF and CSF, etc. Under the circumstances of LPS or zy- mosan, PAF can also induce PMN to release IL--1β and IL--6. All above activate other kinds of inflammatory cells to cascade in- flammatory positive feedback.
PAF不仅直接作用于PMN致PMN趋化、粘附、聚集、脱颗粒、吞噬、呼吸爆发和超氧自由基产生，同时还致炎症介质IL—8、TNF—α、〓、PAF和CSF等释放，而且在LPS或酵母多糖等作用下还可致IL—1β、IL—6释放，从而激活其它炎症细胞形成炎症级联的正反馈反应，剧烈的炎症过程可导致机体损害。
Nuclear factor kappa B, one of the most important transcriptive factors, plays a key role in the expression of many inflammatory mediators.
而核转录因子-KB是一个重要的转录因子，对多种炎性介质的表达起着关键性的调控作用。
PAF is recently considered as a pre--inflammatory mediator, It can activate many kinds of inflammatory cells to pro- duce different kinds of in flammatory mediators to form a complex inflammatroy factor network, which play a pivotal role in inflam- mation onseting and developing.
近年研究认为PAF是一种前炎症介质，可以激活多种炎症细胞产生多种炎症介质形成纷繁的炎症因子网络，在炎症发生发展过程中有重要意义。
Objective To investigate the therapeutic effect of spleen-strengthening, lung-clearing and phlegm-resolving herbs for the treatment of acute attack of chronic obstrustive pulmonary disease complicated with systemic inflammatory response syndrome, and to observe their effect on nuclear factor kB expression level.
观察具有健脾清肺化痰作用的中药汤剂对辨证属于肺脾两虚、疾热郁肺型的慢性阻塞性肺疾病急性发作期合并全身炎症反应综合征患者临床症状、血气分析指标以及对核因子－kB表达的影响。
To study Mica granule's treatment on rats'ethanoic acid colitis and the possible mechanism. After modelling, apply Mica suspending liquid for enema once a day, observe demonstration under microscope and enteric mucosa injury at 3th day and 14th day, measure EGF and TNFa in serum and colon tissue. Result The Mica had improvements on colon mucosa injury and tissue of rats with colitis generally, meanwhile it could comparatively add EGF the repair factor in colon and serum of rats, also decrease inflammatory factor TNFa.
目的］研究云母颗粒对大鼠乙酸性结肠炎的治疗作用及可能机制；［方法］造模后用云母混悬液灌肠，每天一次，观察造模后第3天及第14天时结肠黏膜损伤程度和光镜下表现，测定血清及结肠组织中的EGF、TNFa含量；［结果］云母第3天和第14天时对乙酸性结肠炎大鼠结肠黏膜损伤大体观及组织学均有改善作用，同时使大鼠血清及结肠组织的修复因子EGF含量相对增加，致炎因子TNFa含量相对降低。
Previous studies have documented that luminal exposure to bacterial lipopolysaccharide augments enterocytic cell death in dose- and time-dependent manner, whereas others reported the activation of a pro-inflammatory transcription factor, i. e. nuclear factor kappa B upon LPS challenge, in intestinal epithelial cell lines.
过往利用肠道上皮细胞株之研究发现细菌内毒素（lipopolysaccharide，LPS）在肠腔面的刺激会增加细胞凋亡的现象并呈现时间与浓度之依赖性，另一方面亦有文献指出LPS能活化细胞中促发炎反应之转录因子nuclear factor kappa B。
We have shown previously that the dithiol compound -lipoic acid exerts antiinflammatory effects by inhibiting tumor necrosis factor-– and lipopolysaccharide-induced endothelial and monocyte activation in vitro and lipopolysaccharide-induced acute inflammatory responses in vivo.
过去我们已证实二硫醇复合物-LA能够通过抑制肿瘤坏死因子及体外脂多糖诱导的内皮、单核细胞的活化和体内脂多糖诱导的急性炎症反应来发挥抗炎作用。
It can not only boost the abilities of phagotosis, disposal and presentation of antigens but also excrete multiple cytokines and chemotaxis mediators such as interleukin 1β(IL-1β), tumor necrosis factor α, macrophage inflammatory protein and leukotriene B4 (LTB4), et al, promote T and B cells to proliferate and mature, collect neutrophil to lung, raise the immune ability of lung to resist the bad effect from exotic materials.
从而既提高自身吞噬、处理、递呈抗原的能力，又分泌多种细胞因子和化学趋化因子，如白介素1β(IL-1β)、肿瘤坏死因子α、巨噬细胞炎症蛋白以及白三烯B4(LTB4)等，促进T、B 细胞的增殖、成熟，募集中性粒细胞至肺，全面提高肺的免疫能力以抵御外来刺激物的不良作用。
2 The latest study of pathogenesis of T2DM、IR The results and progresses of study on glucose and lipid metabolism, inflammatorypathogenesis and the nuclear factor-κB、the monocyte chemoattractant protein-1(MCP-1), and IRS-2 were summarized involving the inflammatory pathogenesis of T2DM、IRat home and abroad in recent years.
1.2 2型糖尿病胰岛素抵抗现代医学研究进展对近年来国内外关于糖、脂代谢，炎症及炎症因子NF-κB、MCP-1，IRS-2在2型糖尿病、胰岛素抵抗中的作用机制最新研究动态进行了综述。