Intermediate I was reduced at -78℃ by DIBAL-H to obtain benzo[l, 2, 3]thiadiazole-7-carbaldehyde, and benzo[l, 2, 3]thiadiazole-7-carbaldehyde treated via Wittig-Horner reaction to-3-(benzo[l, 2, 3]thiadiazol-7-yl)acrylic acid esters as target compounds.
中间体Ⅰ在低温-78℃下经二异丁基氢化铝还原制备了苯并[1，2，3]噻二唑-7-甲醛，随后苯并[1，2，3]噻二唑-7-甲醛经Witting-Homer反应制备了目标产物-苯并[1，2，3]噻二唑-7-丙烯酸酯。
On the other hand, reaction of lactol derived from D-mannose and D-glucose with Grinard reagent of propargyl bromide also proceed both withanti stereoselectivity and with high anti-specificity.
链增长及目标分子中的碳碳双键是由一步Wittig反应和一步末端炔的烷基化再部分氢化而获得，双键构型-选择性可达到95％以上。
Chapter 2 Some novel Aza-Wittig regents were synthesized under mild conditions, their reaction performance was studied, and the reaction mechanism of these Aza-Wittig reagents with phenyl isocyanate was speculated.
第二章主要研究了在温和条件下一些新型的Aza-Wittig试剂的合成及其反应性能，并对新型的Aza-Wittig试剂与异氰酸苯酯的反应机理进行了推测。
Methods Triethyl phosphite and ethyl chloroacetate were used as starting materials to synthesize pregabalin by Arbuzov reaction, Wittig-Horner reaction, Michael addition, reduction and resolution.
以亚磷酸三乙酯和氯乙酸乙酯为起始原料，经Arbuzov反应、Wittig-Horner反应、Michael加成、还原、拆分5步反应得到普瑞巴林。
NK-104 was synthesized via a series of reaction steps. Firstly, the substituted quinolinedelyde was synthesized from anthranillic acid via cyclization, reduction, oxidation etc. Secondly, the chiral wittig reagent was synthesized from 3- pentanedioic anhydride via selective asymmetric ring-opening reaction, debenzylation, esteration etc.
新路线从邻氨基苯甲酸出发经付克酰基化、还原、环化、还原、氧化得到取代的喹啉甲醛；再从3-戊二酸酐出发，经不对称开环、脱苄、膦氧化、酯化得到含一个手性中心的膦氧试剂；膦氧试剂再与取代的喹啉甲醛缩合、脱保护、不对称还原水解等共十五步反应完成了NK-104的全合成。
The important intermediate 17β-carboxyl steroid 3-62 and progesterone 3-64 from DHEA were synthesized by wittig reaction, hydroboration-oxidation, oppenauer oxidation, Jone`s oxidation in total yield of 23.0%, 5.7%, respectively.
以脱氢异雄酮为起始原料，与不同的Wittig试剂反应，在17-酮基位分别接枝上亚甲基、亚乙基、乙氧羰基亚甲基、甲氧基亚甲基等侧链，收率分别为96%、95%、53%、10%。
New process for recovering of triphenylphosphine and triphenylphosphine oxide from waste residue was proposed.
用化学反应－结晶联用法从Wittig反应废渣中回收三苯基膦和三苯基氧膦。
This thesis mainly focused on the sidearm effects in catalytic Wittig-type olefination and catalytic asymmetric 1, 3-dipolar cycloaddition between nitrones and alkylidene malonates.
本文主要研究了催化的叶立德烯基化反应及催化的不对称1，3偶极加成反应中的边臂效应。在论文的第一部分，我们设计、合成了聚乙二醇负载的烷基碲化合物33(Bu-Te-PEG-Te-Bu)。
Benzothieno[3, 2-d]imidazol[1, 2-a]pyrimidin-2, 5(1H, 3H)-diones were synthesized from consecutived aza-Wittig reaction.
首次应用aza-Wittig反应合成了苯并噻吩并[3，2-d]咪唑并[1，2-a]嘧啶-2，5(1H，3H)-二酮28。
A general novel synthetic method to Symmetrically or unsymmetrically 2, 3, 6, 7- substituted thieno[2, 3-d:5, 4-d']dipyrimidine-4, 5(3H, 6H)-diones and 2-substituted benzothieno[3, 2-d] pyrimidin-4(3H)-dione by utilizing aza-Wittig reaction was proposed firstly. This synthetic method has the advantage of easily accessible starting material, mild condition and good yields.
具体研究内容如下：1、首次研究了应用aza-Wittig反应方法合成2，3，6，7-对称与不对称四取代噻吩并[2，3-d；5，4-d']双嘧啶-4，5(3H，6H)-二酮以及2-取代苯并噻吩并[3，2-d]嘧啶-4(3H)-酮衍生物的通用新方法，该方法原料易得，条件温和，收率较高。
The reaction of carbodiimide 14 with chiral amino alcohol was studies firstly, a facile synthetic methods for 2-substituted benzothieno[3, 2-d]pyrimidin-4(3H)-one with high ee value, but reacted with chiral amino esters got the racemic product benzothieno[3, 2-d]imidazol[1, 2-a]pyrimidin-2, 5 (1H, 3H)-diones, which boarded the utilization of aza-Wittig in organic synthesis.
首次运用碳二亚胺14与手性氨基醇的aza-Wittig反应，合成了未见文献报道的具有较高ee值的2-取代苯并噻吩并[3，2-d]嘧啶-4(3H)-酮23，而碳二业胺14与手性氨基酸酯的反应则得到消旋化的产物苯并噻吩并[3，2-d]咪唑并[1，2-a]嘧啶-2，5(1H，3H)-二酮28，该反应方法进一步丰富了aza-Wittig反应在有机合成中的应用。
Benzothieno[3, 2-d]imidazol[1, 2-a]pyrimidin-2, 5(1H, 3H)-diones were synthesized from consecutived aza-Wittig reaction. And the results showed that at ambient temperature the gualidene-type intermediates 26 cyclization automaticly to form a five-member ring at the absence of RONa, then condensed to form a six-member ring in the presence of RONa.6. Seven triazole derivatives were synthesized, the spectral properties and its fungicidal activities were studied.
结果表明：室温条件下胍中间体26能自动发生分子内的缩合首先形成一个五员环，而后续的缩合则需要在强碱醇钠的催化下才能顺利进行，得到苯并噻吩并[3，2-d]咪唑并[1，2-a]嘧啶-2，5(1H，3H)-二酮28.6、合成了7个手性三唑醇类衍生物，并对其波谱性质进行了研究。7、对所合成的部分噻吩并嘧啶酮类衍生物和三唑醇类衍生物的杀菌活性进行了测试。
A series of 3--1, 2, 3-triazolo[4, 5-d]pyrimidin-7-ones were synthesized via the tandem Aza-Wittig reaction annulation.
用串联的氮杂Wittig关环反应合成了一系列3--1，2，3-三唑[4，5-d]嘧啶-7-酮。
In this thesis, we describe a facile and economical synthesis of-abscisic acid from keto-isophorone and 3-butyn-2-ol through ketalization, oxidization, Witting-Horner reaction, reduction with chromium sulfate and other steps in 13% total yields. Compared to the previous routes, the starting materials are more commercially available and cheaper and the synthetic process is more easily controlled in our method, but the yield of this route is still to be improved. As to isostere principle, cyclopropyl and methyl vinyl are a couple of isostere.
本论文设计并完成了一条全新的外消旋脱落酸(1)全合成路线，从廉价的工业原料氧化异佛尔酮和丁炔醇出发，经过缩酮化反应、氧化反应、Wittig-Horner反应、CrSO_4选择性还原反应以及水解等七步反应实现了脱落酸的全合成，总产率达13％，与以往路线相比，该路线所用试剂廉价、合成路线简单，但产率有待提高。
A with under strong base butyl Lithium, Wittig reaction was carried out, after cast off extremital 2, 3-dihydropyran which protected hydroxy group, then 5, 14-gadoleyl-1-ol was obtained.
a与在强碱正丁基锂的作用下进行Wittig反应，然后脱去末端的2，3-二氢吡喃保护基，得到5，14-二十碳二烯醇。
Besides, through Arbuzov reaction, Vilsmer-Haack Hydroformylation, Wittig-Horner reaction, nitryl hydrogenation deoxidize, and imidization five steps synthesized another compound which included hole-transporting, electron-transporting and luminescence materials.
此外，又通过Arbuzov反应、Vilsmer-Haack甲酰化反应、Wittig-Horner反应生成二苯乙烯、硝基加氢还原、酰亚胺化5步反应合成了一种集空穴传输-电子传输-发射三位一体的新型苝酰亚胺化合物。
In this paper 8 methodologies for carbon-carbon multiple bond formation have been described.(1)The synthetic utility of β- ketophosphonium salts.
本研究工作包括下列8方面：(1)一种不同于Wittig反应的新的烯化方法，含氟β-酮基磷盐在有机合成中的应用。
Recent advances in aza Wittig reaction, including intermolecular, intramolecular and tandem ones, are reviewed.
综述了最近几年氮杂Wittig反应的研究进展，包括分子间氮杂Wittig反应、分子内氮杂Wittig反应及串联的氮杂Wittig反应。
Part 2: Wittig reaction and double Heck reaction were applied to synthesize a series of fluoro-substituted diphenylamino-dibiphenyl fluorescent materials.
第二部份：我们利用Wittig反应和Double Heck反应合成ㄧ系列含氟原子取代的对二苯胺-对苯二乙烯联苯型萤光材料。
Methods:Started from 2, 6-dibromopyridine, acrivastine was synthesized by acylation reaction, HECK reaction to obtain-3-[6-(4-Methyl-benzoyl)-pyridin-2-yl]-acrylic acid ethyl ester, which was reacted by Wittig condensation affords a cis:trans mixture of-6-[3-(1-Pyrrolidinyl)-1-p-tolyl-propenyl]-2-pyridin-eacrylic acid ethyl ester; then treated with acid, hydrolization and recrystallization.
以2，6-二溴吡啶为起始原料，经酰化反应，HECK反应得到-3-6-[(4-甲苯基)羰基-2-吡啶基丙烯酸乙酯，再经Wittig反应得到-6-[-3-(1-吡咯烷基)-1-(4-甲基苯基)丙烯基]-2-吡啶丙烯酸乙酯，经酸转化，水解，重结晶得阿伐斯汀。