These pathological changes was demonstrated focally and the rest of the angle in CYP1BI-null were normal.
这些异常改变在CYP1B1基因缺失小鼠眼前房角内呈局灶性分布。
RRW moderately induces CYP2B isoenzymes when given orally to mice and rats.
大鼠和家兔在口服 RRW 后，可以对 CYP2B 同工酶产生中度的诱导。
Nevirapine induce cytochrome P450 activity and coadministration with other drugs metabolized by P450 CYP3A or CYP2B may result in lower plasma concentrations of those drugs, so need to adjust the dosage of those drugs when combination use drugs.
奈韦拉平是肝细胞色素P450代谢酶的诱导剂，可以降低主要由CYP3A、CYP2B代谢的药物的血浆浓度。因此，如果一个患者正在接受由CYP3A或CYP2B代谢的药物的一个稳定剂量的治疗，若开始合用本品，前者剂量需要调整。
The profile of liver CYP450 induction by DEX in male rat After 4 daily i. p. administering of 0, 25, 50 and lOOmg/kg/d DEX in male Wistar rat, it was determined the total CYP450 content, the mRNA and protein expression levels of CYP3A1, CYP3A2 and CYP2B1/2, and the ERD (CYP3A catalytic activity), PROD (CYP2B catalytic activity) and BROD (total CYP450 catalytic activity) in livers.
DEX对雄性大鼠肝脏CYP450的诱导效应雄性Wistar大鼠腹注0、25、50和100mg DEX/kg/d诱导处理4天后，测定大鼠肝脏总CYP450含量，CYP3A1、CYP3A2和CYP2B1/2的mRNA及蛋白表达水平，肝脏红酶素脱甲基酶(ERD，CYP3A活性)，苄氧基试卤灵脱乙基酶(PROD，CYP2B活性)，苯氧基试卤灵脱乙基酶(BROD，总CYP450活性)，结果表明，CYP450含量、ERD、PROD和BROD在DEX多次诱导后都有升高，CYP3A1 mRNA表达水平、蛋白含量和酶活性有明显的升高，剂量效应关系明显；CYP3A2蛋白也有明显升高，而其mRNA表达水平却没有变化，提示CYP3A1和CYP3A2的诱导机制可能不同。
The profile of liver CYP450 induction by DEX in male ratAfter 4 daily i. p. administering of 0, 25, 50 and lOOmg/kg/d DEX in male Wistar rat, it was determined the total CYP450 content, the mRNA and protein expression levels of CYP3A1, CYP3A2 and CYP2B1/2, and the ERD (CYP3A catalytic activity), PROD (CYP2B catalytic activity) and BROD (total CYP450 catalytic activity) in livers.
DEX对雄性大鼠肝脏CYP450的诱导效应雄性Wistar大鼠腹注0、25、50和100mg DEX/kg/d诱导处理4天后，测定大鼠肝脏总CYP450含量，CYP3A1、CYP3A2和CYP2B1/2的mRNA及蛋白表达水平，肝脏红酶素脱甲基酶(ERD，CYP3A活性)，苄氧基试卤灵脱乙基酶(PROD，CYP2B活性)，苯氧基试卤灵脱乙基酶(BROD，总CYP450活性)，结果表明，CYP450含量、ERD、PROD和BROD在DEX多次诱导后都有升高，CYP3A1 mRNA表达水平、蛋白含量和酶活性有明显的升高，剂量效应关系明显；CYP3A2蛋白也有明显升高，而其mRNA表达水平却没有变化，提示CYP3A1和CYP3A2的诱导机制可能不同。
Eight drugs were used in the inhibition assay, to investigate the influence of SNP on drug metabolism.
对CYP3A4野生型及其突变株的研究表明：用酿酒酵母表达人的药物代谢酶是研究与药物代谢相关问题的一个很好途径。
Regulation, function, and tissue-specific expression of cytochrome p450 CYP1B1.Annu Rev Pharmacol Toxicol, 2001, 41(1):297-316.[20] Gribben JG, Ryan DP, Boyajian R, et al.
因此，构建更加稳定的投放载体仍有待解决；⑤UTA肿瘤疫苗的疗效和安全性问题尚待进一步的验证。
Evaluate the effect of nicotine sublingual tablet on smoking cessation. 2. Investigate whether cytochrome P450 gene (CYP1A1, CYP2D6), NAD H-quinone oxidoreductase gene (NQO1) and microsomal exppoxidase hydrolase gene polymorphisms affect nicotine dependence and smoking cessation outcome.
研究目的1：评价尼古丁舌下含片戒烟治疗的疗效，2：探讨细胞色素P450酶基因（CYP1A1、CYP2D6），还原型辅酶Ⅰ醌氧化还原酶基因（NQO1）和微粒体环氧化物水解酶基因多态性对于尼古丁依赖严重程度及尼古丁舌下含片戒烟治疗结果的影响。
Overexpression of several P450 genes from CYP9 and CYP6 families were reported to be associated with xenobiotic detoxification in H.
属于CYP9和CYP6家族的多个P450基因的过量表达与棉铃虫对外来化合物的解毒代谢有关。
Objective To investigate the effect of methyl protodioscin on seven cytochrome P450 enzymes in human liver microsome.
摘要目的研究甲基原薯蓣皂苷对CYP450酶的7种亚型酶活性的影响。
OBJECTIVE To investigate the effects of Folium Isatidis on the activity and mRNA expression of CYP2E1 in mouse liver microsome.
目的：了解大青叶对细胞色素P450 2E1(CYP2E1)酶活性及其信使核糖核酸表达的影响。
Cerebrotendinous xanthomatosis is a rare autosomal recessive disorder of bile acid synthesis, caused by impaired hydroxylation of cholesterol side chains due to deficiency of the mitochondrial enzyme sterol 27-hydroxylase （CYP27A1）, leading to accumulation of cholestanol and cholesterol in brain and other tissues.
文章摘要：脑腱黄瘤病是一种罕见的常染色体隐性遗传性胆汁酸合成障碍，由线粒体酶固醇27-羟化酶（CYP27A1）缺陷所致胆固醇侧链羟化受损引起，从而导致胆固烷醇和胆固醇在脑和其他组织贮积。
This observation lower plasma cholestanol,
上述观察可能暗示激素可降低血浆胆固烷醇水平，该作用可能通过直接诱导残留CYP27A1活性或通过诱导胆固烷醇清除的旁路途径完成。
It is well known that cytochrome P-450 monooxygenase system plays an important role in the metabolism of endogenous and exogenous compounds. Despite the world-wide consumption of licorice and its natural constituent, their possible effects on the multienzymatic microsomal monooxygenase CYP-dependent system and phase Ⅱ transferase, therefore, on the metabolism of endobiotics and coadministered drugs have not been analyzed to date. However, a number of serious side effects related to clinical use have been observed. On this basis, it seems very important to study also the specific effects possibly mediating some deleterious effects of chemicals, such as toxicity/cotoxicity and comutagenicity promotion. These toxic effects related to carcinogenesis, can be investigated by modulation of specific CYPs on which critical activation is dependent.
细胞色素P450超家族是具有复杂功能的酶系统，在代谢转化过程中参与许多前毒物或前致癌物的活化，与人类多种疾病如急慢性肝病和肿瘤的发生、发展以及药物不良反应密切相关。18α-甘草酸（18α-glycyrrhizic acid，GL）是从天然甘草中差向异构筛选而得的有效单体，研究GL对肝药酶的影响及其在肝微粒体的代谢特征有利于阐明其药理作用机制，探讨肝病和肿瘤等疾病的发病机理，对于开发抗肿瘤药、抗肝炎药以及其它疗效高、不良反应少的新药有着十分重要的意义；当临床上几种药物合用时可根据对肝药酶的诱导或抑制适当增加或减少用药量，从而指导对现有药物的合理使用，达到满意的疗效和减轻副作用的效果。
The Arabidopsis CYP81F2 gene encodes a P450 monooxygenase that is essential for the pathogen-induced accumulation of 4-methoxyindol-3-ylmethyl glucosinolate, which in turn is activated by the atypical PEN2 myrosinase (a type of β-thioglucoside glucohydrolase) for antifungal defense.
拟南芥CYP81F2基因能都编码一种P450单加氧酶，这对4甲氧基-3二甲胺基芥子油甙的病原体诱导积累物是十分重要的。反过来，它也能被非典型PEN2黑芥子酶激活，以产生抗真菌的防御作用。
Pharmacogenomic data including both the CYP3A5*3 polymorphism and messenger ribonucleic acid expression levels of MDR1, CYP3A4, and CYP3A5 in the native intestine and the graft liver at transplantation were obtained from 65 of the recipients.
我们从65名小儿肝移植移植受体的案例中获得了药物基因数据，包括移植中原小肠和移植肝的CYP3A5*3基因型多态性和MDR1、CYP3A4和CYP3A5的信使RNA表达。
The activity of CYP2E1was evaluated by measuring chlorzoxazone, a drug probe for CYP2E1, and its metabolites were detected by HPLC.
本实验用探针药物法，通过体内实验来评价黄芪对CYP 2E1活性的影响，CYP 2E1底物为氯唑沙宗［3，4］。
The CYP2C19*2 and CYP2C19*3 are polymorphiysm characterized by its specific single point mutations. The fragment containing the hot spot can be analyzed by DNA autosequencing after polymerase chain reaction amplification.
因CYP2C19*2及CYP2C19*3对偶基因之主要变异点皆为单一碱基突变，可利用聚合酶连锁反应将带有变异点之片段放大后，再利用核酸自动定序仪来进行变异点的鉴定。
The expression of cytochrome P-450 CYP4A mRNA was detected by in situ hybridization in bronchus endothelia and vascular endothelial cells of lung tissue slice.
结果①Western印迹法分析结果表明，细胞色素P450CYP4A蛋白在牛肺动脉内皮细胞和平滑肌细胞中均有表达，在肺动脉内皮细胞中的表达明显高于平滑肌细胞（积分吸光度值分别为10182 279，5249 167）；在牛肾动脉内皮细胞中也有表达，但明显低于肺动脉内皮细胞的表达（积分吸光度值分别为12173 171，17863 207）。
The highest level is expressed in corpus lutea.
CYP51蛋白在黄体上的表达量最强。