A morphometric analysis was performed on a large number of cells from each disease group which induded acute lymphoblastic leukemia, B-chronic lymphocytic leukemia, large granular lymphocytic leukemia, T-prolymphocytic leukemia, Hairy cell leukemia, Splenic lymphoma with villous lymphocytes, leukemia/lymphoma and multiple myeloma.
对一组淋巴源性肿瘤(包括急性淋巴细胞白血病、B细胞-慢性淋巴细胞白血病、大颗粒淋巴细胞白血病、T细胞-幼淋巴细胞白血病、毛细胞白血病、伴绒毛淋巴细胞脾淋巴瘤、白血病-淋巴瘤、多发性骨髓瘤)在透射电镜下观察其形态改变并进行了分析。
Disarrangement of regenerated hepatic cell nodus and liver cell cord, fatty degeneration in hepatic cell, thickening of spleen capsule and serious congestion of spleen parenchyma, atrophy of white pulp and shrinking of follicle and germinal center R50%NSG and RNSG could be seen that hepatic fibrosis, spleen capsule thichening and congesition of splenic parenchyma to a less extent.
脾内纤维严重增生。R50％NSG和RNSG光镜下见肝纤维化程度减轻，脾包膜变薄，脾实质轻度充血。
This study was designed to examine the effect of 3-month-swimming training on cytotoxic activity of natural killer cells and splenic cell IL-2 production in mice.
本文对游泳训练三个月后的C＿（57）BL／6小鼠NK细胞杀伤功能和脾细胞IL－2产生能力进行了研究。
Results: CAZ increased the phagocytosis and ADCC mediated by macrophages; descreaed the number of CD4+ T lymphocytes; had no significant effect on the B cell density in the germinal center of splenic follicles, PMN-CL and ACP activity of the macrophages.
结果：CAZ增强巨噬细胞的吞噬功能及ADCC活性；降低CD4+ T淋巴细胞亚群；对脾小结生发中心B细胞密度、PMN-CL及巨噬细胞ACP活性无影响。
RESULTS the B cell density in the germinal center of splenic follicles had no significant alteration in each groups; the number of CD4+ T cells was significantly lower in pneumonia rats; IPM enhanced the number of CD3+ T cells; CAZ and AMK decreaed the number of CD3+ and CD4+T cells.
结果 5种抗生素对脾生发中心B细胞密度无显著影响；肺炎大鼠CD+4细胞显著降低；IPM使CD+3、CD+4细胞增多，呈现促进作用；CAZ使各细胞亚群均减少，尤以CD+8减少更明显；AMK降低CD+3、CD+4细胞，呈现抑制作用。
Results All the examination results of the experimental group in comparison with the control show the ability on transformation and proliferation of splenic lymphocyte were raised; the quantity of the mice antibody-producing cell and the sheep erythrocyte antibody levels in serum increased; the ability of mononuclear macrophage eliminating carbon and mononuclear celiac macrophage phagocytic activity were raised; the delayed allergy was accelerated; but the activity of NK cell was no obvious raised.
结果 各剂量组的各项检测结果与阴性对照组比，均能刺激小鼠脾淋巴细胞增值、转化作用，促进小鼠迟发型变态反应作用，提高小鼠抗体生成细胞，提高小鼠的血清溶血素水平，增强小鼠的单核-腹腔巨噬细胞吞噬和碳廓清能力，但对小鼠NK细胞活性功能无明显作用。
Results all the examination results of the experimental group in comparison with the control show the ability on transformation and proliferation of splenic lymphocyte were raised; the quantity of the mice antibody-producing cell and the sheep erythrocyte antibody levels in serum increased; the ability of mononuclear macrophage eliminating carbon and mononuclear celiac macrophage phagocytic activity were raised; the delayed allergy was accelerated; but the activity of nk cell was no obvious raised.
结果 各剂量组的各项检测结果与阴性对照组比，均能刺激小鼠脾淋巴细胞增值、转化作用，促进小鼠迟发型变态反应作用，提高小鼠抗体生成细胞数，提高小鼠的血清溶血素水平，增强小鼠的单核-腹腔巨噬细胞吞噬和碳廓清能力，但对小鼠nk细胞活性功能无明显作用。
Results Compared with the results of controls the Radix spirulina was capable of stimulating the proliferation and transformation of splenic lymphocyte of mice of experimental group; the quantity of antibody-producing cell and the sheep erythrocyte antibody levels in serum of mice of experimental group were increased; the ability of mononuclear macrophage eliminating carbon and mononuclear celiac macrophage phagocytic activity were raised; the delayed allergy was accelerated; but the activity of NK cell was no obvious raised.
结果 各剂量组的各项检测结果与阴性对照组比，均能刺激小鼠脾淋巴细胞增值、转化作用；促进小鼠迟发型变态反应作用；提高小鼠抗体生成细胞数和血清溶血素水平，增强小鼠的单核-腹腔巨噬细胞吞噬和碳廓清能力，但对小鼠NK细胞活性功能无明显作用。
Extract and a control group were divided. The Immune function of Solanum lyratum Thunb. extract was studied on normal mice through the following indices:splenic lymphocyte transformation efficiency, delayed type allergy, NK activity, antibody―forming cellsactivity, rate of carbon clearance, and rate of peritoneal macrophage phagocytizing chicken red blood cell.
实验设3个浓度的药物组和空白对照组，对其进行正常小鼠脾淋巴细胞转化实验、迟发型变态反应、NK细胞活性测定、抗体生成细胞的检测、腹腔巨噬细胞吞噬鸡红细胞、碳廓清实验等实验。
The experiment object is healthy and adult Sprague-Dawleyrat whose weight is 275±25 g as well as female and male is half. Routine prepare rat splenic lymphocyte suspension, adjust cell concentration to 2×106/ml.
本研究选取健康成年SD大鼠(体重为275±25 g，雌雄各半)为研究对象，常规制备大鼠脾淋巴细胞悬液，调细胞浓度至2×106/ml。
Objective To study the antigenpresenting function of splenic dendritic cells in mice after hemorrhage plus closed fracture. Methods Splenic DCs were isolated 24h after hemorrhage plus closed fracture, then the ability to stimulate nonadherent splenocytes proliferation in the presence of conalbumin in vitro was detected, IL12 and IL10 levels in cell supernatants were measured by ELISA kits.
大量研究表明，创伤能引起机体免疫系统产生复杂的变化，树突状细胞(dendritic cells，DC)是体内功能最强的专职抗原递呈细胞(antigenpresenting cells，APC)，它可摄取和加工抗原，并分泌多种细胞因子，在激发T 细胞的免疫应答中起重要作用。
The immune status of recipients with gene-transfected kidney were assessed by determining the reaction of recipients splenic cells to donors and the third party's splenic cells. The results showed that a hyporesponsiveness to donor occurred while the normal reaction to the third paity was retained, which suggest that a donor-specific hyporesponsive status be induced in the recipients. The effect of exogenous IL-2 on the survival of gene-transfected renal allografts was observed. The results showed that the effect of CTLA-4Ig gene transfection in kidney could be abolished by exogenous IL-2 administrated between 3～5d after transplantation but could not be abolished by the same management between 15～17d after transplantation, whichi imply that T cell angery may be the early mechanism of donor-specific hyporesponsiveness induced by CTLA-4Ig gene transfection in kidney and then the mechanism other than T cell angery be developed to maintain hyporesponsiveness in that setting.
以MTT法检测受体脾细胞对供体和无关大鼠脾细胞的刺激反应显示：受体在对无关抗原保持正常免疫反应的同时出现了对供体抗原特异性的免疫反应低下状态，表明CTLA-4Ig基因局部转染所诱导的受体免疫反应低下状态具有供体抗原特异性；观察了外源性IL-2对CTLA-4Ig基因转染移植肾存活的影响，结果显示：术后3～5d应用外源性IL-2消除了CTLA-4Ig基因转染延长移植肾存活的作用，移植肾仅存活8.8±2.1d，而术后15～17d应用外源性IL-2对CTLA-4Ig基因转染移植肾的存活无明显影响（移植肾存活29.2±5.8d），该结果间接表明：使抗原特异性T细胞无能可能是CTLA-4Ig基因局部转染使受体产生免疫反应低下状态的早期作用机制，其后，通过T细胞无能以外的机制维持免疫反应低下状态，因此不能被外源性IL-2逆转。
Results The rat splenic weight of the group A and the group B taking CsA for two months showed no significant difference, and the pathological change was seen that not only all the rats spleen in group A and group B had a atrophy, but also splenic corpuscle atrophy existed, lymph node cell decreased obviously. It indicated that the longer time of having immunosuppressive agent and taking more dosage of the drug may induce the severity atropy in rat spleen. The splenic index of the group A'(transplantation patients for three years) showed no significant difference, but group B', C'were different.
结果 A组的大鼠脾脏重量及CsA灌胃2月B组的大鼠脾脏重量无显著性差异，而CsA灌胃3个月B组的大鼠脾脏重量有非常显著性差异，同时病理观察发现：A、B组的大鼠脾脏均有萎缩现象，脾小体萎缩，淋巴结细胞明显减少，而且随CsA药物剂量增加及服用CsA时间延长，老鼠脾脏萎缩程度加重；肾脏移植术后口服免疫抑制剂A'组的病人脾脏指标无显著性差异，B'，C'组的病人脾脏指标存在显著性差异，脾脏萎缩明显。
To study the effect of HEP on the Splenic cell metabolic activity, distribution of T lymphocyte subsets and the secretion of cytokine of normal mice. Method: 1. Established immunosuppression animal model by cyclophosphamide induction.
研究猴头菇多糖对正常小鼠脾细胞代谢活力、T淋巴细胞亚群的分布及细胞因子分泌的影响。方法：1.采用环磷酰胺诱导建立免疫抑制动物模型。
On the other hand, delayed-type hypersensitivity, and splenic cell mitogen responses to phytohemagglutinin and concanavalin A did not differ among mice fed the various diets.
另一方面，各组在迟发超敏反应、脾细胞分裂素对植物血球凝集素与伴刀豆球蛋白A的反应并无不同。
Results: A1 could notably promote the function of antibody formation of the splenic cell (P < 0.05); though A2 and A3 had certain promotion function, too, there was no statistical significance;
结果；A1可以明显促进脾脏抗体形成细胞的功能（P＜0.05），A2、A3虽也有一定的促进作用，但无统计学意义；
Effects of Bacillus Calmette-Guerin vaccination on immune functional development of splenic T cell in neonatal mice
新生期小鼠卡介苗接种对脾脏T细胞功能亚群发育的影响
Methods: Hepatic metastases model were established in 615 mice by splenic injection of proventriculus squamous carcinoma cell (MFC).
方法：建立小鼠前胃癌细胞经脾接种肝转移小鼠模型，随机分为两大组。
Quantitative alteration of splenic cell subpopulation in newborn guinea pigs with acute cytomega lovirus infection
急性巨细胞病毒感染导致新生豚鼠脾细胞亚群的定量改变
According to the steep drop of number of splenic cells with increase of radiation dose, it was further ascertained that relative radioresistance was present in NK, cells, indicating radiation hormesis on NK cell activity at lower doses of radiation was possible.
根据全脾细胞数量随照射剂量增加发生的急剧变化，进一步验证了NK细胞具有相对辐射抗性。基于本实验结果，提出了低剂量辐射对NK细胞活性可能具有辐射刺激作用。