The state-of-the-art methods collected here are designed to analyze the relationship between chromatin structure and function, and to elucidate the molecular mechanisms that control such vital cellular functions as transcription, replication, recombination, and DNA repair.
Chromatin Protocols|Chromatin 协议收集的最新型的方法被用於分析在chromatin 架构和功能之间的关系，阐明控制象抄写这样的至关重要细胞功能的分子机制，复制，重新结合和DNA 修理。
The chip used contains 4097 genes covering oncogenes and tumor suppressor genes, the genes related to ion channels, cell cycle proteins, outer force reaction proteins, cell skeleton and movement, and apoptosis, the genes associated with DNA synthesis, repair and recombination, the genes related to DNA combining and transcription, the genes encoding cell receptors, the genes related to signaling, the genes associated with immune response, metabolism, protein synthesis, development and others.
实验所用的芯片含有4097个基因，包括原癌基因和抑癌基因、离子通道和运输蛋白基因、细胞周期蛋白基因、外压反应蛋白基因、细胞骨架蛋白和运动相关基因、细胞凋亡相关蛋白基因、DNA合成和修复和重组相关蛋白基因、DNA结合和转录和转录因子基因、细胞受体基因、免疫相关基因、细胞信号传导蛋白基因、代谢相关蛋白基因、蛋白质翻译和合成相关基因、发育相关基因、及其它基因。
The newly discovered proteins, SMC (structural maintenance of chromosome) proteins, are associated with chromosome dynamics change in the cell cycle. They are involved in chromosome condensation, sister-chromatid cohesion, sex-chromosome dosage compensation, genetic recombination and DNA repair, etc.
近年来新发现的一类蛋白――染色体结构维持蛋白(SMC蛋白，structural maintenance of chromosome proteins)与染色体结构细胞周期性的动态变化紧密相关，它们参与有丝分裂染色体的集缩和分离、性染色体的剂量补偿效应、姐妹染色单体的内聚作用、遗传重组和DNA修复等过程。
For maintain the genome integrity and fidelity. DNA repair processes are classified into pathways responsible for repairing specific classes of DNA damage, although recent data indicated that some proteins function in multiple pathways. Base excision repair occurs through excision of a damaged region, followed by fill-in repair synthesis using the opposite strand as a template. Mismatch repair operates on base mismatched and small loop-outs that arising during replication by misincorporation or slippage on the template strand. Nucleotide excision repair removes photoproducts from u. v. radiaton and bulky adducts from a multiple of chemicals. DNA double-strand breaks may be rectified by either homologous recombination repair and nonhomologous end joining pathways where both strands of the DNA duplex are damaged.
DNA修补基因可藉由不同的机制对不同程度的DNA损害进行修复，虽然近来已有文献指出，一些DNA修复蛋白可能参与多种DNA修复机制，不过一般可分为下列四种DNA修复机制：碱基删除修复(Base Excision Repair； BER)，即对较小的DNA损伤，进行修复；核苷酸错误配对删除修复，即对复制时所产生的核苷酸配对错误或模板滑动造成的DNA损害进行修复；核苷酸删除修复(Nucleotide Excision Repair； NER)，即对因紫外线或有机化合物所造成的较大损伤进行修复；以及双股DNA断裂修复(Double-Strand Breaks； DSBs)，即对双股DNA断裂进行修复，此机制又可分为同源染色体的重组与末端接合两种主要路径，对受损的DNA进行修复。
The artificial prosthesis, inactivation replantation and bovine bone transplantation were used fon the repair of massive bone defect and function recombination of joint in 20 cases of primary malignant bony tumor and better limb retention and functionl recovery were gained.
对20例原发骨肿瘤应用人工假体、灭活再植、牛骨移植三种方法修复大块骨缺损及关节功能重建，获得较好的肢体保留及功能恢复。
Study of interaction of E. coli single-stranded DNA - binding protein (SSB) with its substrate, single-stranded DNA (ssDNA), is very important for understanding its essential roles in replication, recombination and repair of DNA.
研究大肠杆菌单链结合蛋白（single-strandedDNA-bindingprotein，SSB）与单链DNA（single-strandedDNA，ssDNA）的相互作用对于了解其在DNA复制、重组和修复中的作用是非常重要的。
OBJECTIVE: To investigate RAG gene, DNA repair factors Ku70/Ku80 and terminal deoxynucleotidyl transferase (TdT) mRNA expression and T cell receptor (TCR) gene recombination in human leukemia and lymphoma cell lines.
目的：检测重组激活基因、DNA修复因子Ku70/Ku80和末端脱氧核苷转移酶mRNA表达以及T细胞受体基因重排在人白血病和淋巴瘤细胞株的发生情况。
There are complete repair system in normal cells, including base excision repair system (BER) and homologous recombination repair system (HR).
人类细胞内存在着完整的修复系统，其中包括碱基切除修复系统（baseexcisionrepair，BER）和同源重组修复系统（HomologousRecombination，HR）。
There are many DNA repair pathways to different DNA lesions, including base excision repair, nucleotide excision repair, mismatch repair and homologous recombination repair.
针对不同的DNA损伤。细胞内有许多不同的修复方式对其进行修复，包括碱基切除修复、核苷酸切除修复、错配修复、同源重组修复等。
Most members of the XRCC genes family participated in several DNA repair pathways, including base excision repair, homologous recombination repair and non-homologous end joining.
目前已鉴定的这一基因家族的多数成员均参与几种重要的DNA修复途径，包括碱基切除修复、同源重组修复和非同源末端重接。
Objective To investigate HR24L repair complex after DNA damage induced by radiation and provide biochemical evidence of the participation of HR24L in DNA excision repair and recombination repair.
目的探讨辐射损伤后HR24L修复蛋白复合物的形成，为HR24L参与切除修复和重组修复提供生化证据。
Objective To study the liver cancer specific DNA damage response/repair/recombination gene expression profile and the difference between liver cancer tissues and their adjacent normal tissues.
目的了解肝癌中DNA损伤修复/DNA重组有关基因的表达概况，探索在肝癌与正常肝组织中的表达差异。
While others like cellular period protein, cytoskeleton and movement protein, receptor genes, DNA demage, repair and recombination, etc.
而在细胞周期蛋白、细胞骨架和运动、细胞受体、DNA合成和修复及结合和转录等方面则关联甚少。
In Escherichia coli, it takes part in conjugational recombination and DNA repair but is not as important as that in archaea.
在大肠杆菌中，RadA蛋白也参与了重组和DNA损伤修复过程，但远没有在古细菌中的功能那么重要。
The recA gene is known to be the key gene in DNA recombination and SOS repair of DNA damage.
前人的工作证明了recA基因的DNA重组和DNA损伤应急修复过程中是一个关键的基因。