It is clear that mechanisms of arsenic carcinogenesis is chromosome abnormality rather than DNA damage As a clastogen, arsenic induces chromosome break, translocation to the some special gene regions of the other chromosome, which might make rearrangement of gene and activate oncogens.
与DNA损伤效应不同，砷是断裂剂，引起染色体断裂，可能因易位到另外染色体的某些基因区域上，形成基因重排、激活癌基因而致癌。
Results consistently demonstrate that A-CM preperation has significant antimutagenic effect on gene mutation and chromosome clastogen in all above tests.
体外试验可有效防护H2O2对人血白细胞DNA的氧化损伤。提示A－CM制剂对某些毒物诱发的DNA和染色体水平的突变均有一定抵抗作用
Basis on auther`s new automatic flow cytometric technique for micronuclei, a lot micronuclei induced by clastogen Mitomycin C and aneugen colcemid were collected on slides using sorting function of flow cytometry, them the centromere Gamma satellite DNA probes of mouse (about 234bp) was used to do in situ hybridization for micronuclei, furthermore, the kinetochores of micronuclei can be showed, and the micronuclei which consist of the whole chromosomes or the chromosome fragments, can also be indicated.
本文报道用作者建立的流式细胞仪红细胞微核自动检测技术，将染色体断裂剂丝裂霉素C和非整倍体毒剂秋水仙碱诱导的大量微核分选在载玻片上，然后使用小鼠着丝粒γ-卫星DNA探针(约为234bp)，对分选微核进行荧光原位杂交，以显示微核内着丝粒的情况，进而判定M N是由整条染色体还是由染色体断片组成。