Glycation and AGEP formation are also accompanied by formation of free radicals via autoxidation of glucose and glycated proteins.
糖化和AGEP形成同时也伴随着葡萄糖和糖化蛋白的自动氧化导致自由基形成。
Methods AGEP-BSA was prepared by incubating bovine serum albumin with glucose of 0, 20, 50, 80mmol*L-1 at 37℃.Effect of I-93 on 200 mg*L-1 AGEP-stimulated proliferation of ASMC derived from aorta of Sprague-Dawley rats was studied with [3H]-TdR incorporation and MTT assay.
目的：观察3，6--二苯骈碘杂六环葡萄糖酸盐对AGEP引起的大鼠主动脉平滑肌细胞增殖及牛主动脉内皮细胞内皮素和一氧化氮改变的影响。
Methods: A comprehensive analysis of data, including etiology, clinical manifestations, laboratory and histological findings, diagnosis and differential diagnosis, of 11 patients with AGEP induced by drugs were made.
方法：分析11例急性全身性发疹性脓疱病的病因、症状、体征、实验室检查和病理，诊断及鉴别诊断。
CONCLUSION: AGEP enhanced MCP-1 mRNA expression in human PBMC.
结论：AGEP能增加人血单核巨噬细胞MCP-1基因的表达。
Two differentially expressed cDNA fragments were isolated from kindled rat cortex and hippocampus GAK 1 and GAK4 The two cDNA fragments confirmed by Dot and Northern blot analysis and in situ hybridization The results show that the piriform cortex of kindled rat expressed more the GAK1 than the non-kindled and control piriform cortex, and GAK4 expressed in the piriform coxtex, entorhinal cortex, amygdala and hippocampus of both of non-kindled and control rat but not in the cortex and hippocampus of kindled rats GAK1 and GAK4 were then sequenced and show no significant homology to any publisled genes The above results suggest that GAK1 may be an unknown gene associated with kindling, GAK4 may be a novel gene associated with antikindling gene This study provides the first evidence to show that there is alteration in gene expression associated with kindling by using the DDRT- PCR
从点燃大鼠脑内分离和确认了两个差异表达的cDNA片段GAK-1和GAK-4。经Dot和Northern杂交分析显示：GAK-1在点燃大鼠皮层内的表达明显高于未点燃和对照大鼠；GAK-4的表达却只出现在未点燃组和对照组大鼠的皮层和海马。进一步的原位杂交分析显示：GAK-1主要分布在点燃大鼠的梨状皮层：GAK-4则主要分布在未点燃和对照组大鼠的梨状皮层、内嗅皮层、杏仁核和海马内。测序结果显示：GAK-1与已发表的基因没有显著的同源性；GAK-4与编码AGEP受体的基因有90％的同源性。本实验结果提示，GAK-1可能是一个未知的点燃致痫相关基因而GAK-4则可能与对抗点燃相关。
Results: of 20 patients with AGEP, 18 are drug induced and the other 2 are not clear.
结果20例患者中，18例由药物诱发，另外2例原因不明。
AIM: To study the effect of removal of hemodialysis using acetate membrane on serum advanced glycosylation end products (AGEP) in 36 patients (59.1 ± 1.6) with end stage renal disease (ESRD).
目的：研究血液透析对36例终末期肾病患者血中高级糖基化终产物的清除效果。