A key regulatory gene of TetR/AcrR family, acrR, was inactivated through the introduction of an internal stop codon resulting in overexpression of AcrAB that appears to be associated with ciprofloxacin resistance.
一个TetR/AcrR家族中调控基因acrR由于在其基因中产生了终止密码子而失去了活性，导致与环丙沙星抗性相关的基因AcrAB的过量表达。
Tarda AcrAB multidrug resistance system was cloned in this study. Sited-directed mutation was used to determine the promoter sequences of acrAB and acrR and the AcrR binding site.
论文克隆分析了迟缓爱德华氏菌AcrAB耐药系统，采用定点突变确定了acrAB、acrR的启动子序列和AcrR在acrAB启动子的结合位点。
The inhibitors of NorA, Mex, Tet (B) and Acr-TolC that discovered in recent years were reviewed in this paper.
本文综述了近年来细菌外排泵NorA、Mex、Tet（B）和AcrAB-TolC抑制剂的研究进展情况。
The investigation suggests that Mar phenotype of Escherichia coli be determined by the levels of active efflux system acrAB gene expression, and the expression of acrAB gene should be regulated by mar operon.
本研究表明大肠杆菌acrAB表达水平决定了大肠杆菌多重耐药表型，mar可能调控acrAB的表达。
Conclusion: The multiple-antibiotic-resistant active efflux system gene acrAB of Salmonella typhi shows high homology in bases, amino acids and protein structure with that of Escherichia coli and it is the possible reason that Salmonella typhi is resistant to multi-antibiotics without similar chemical structure.
结论：伤寒沙门菌acrAB主动外排系统在结构、碱基序列和编码的氨基酸序列上均与大肠杆菌有很高的同源性，它可能是伤寒沙门菌引起多重耐药的主要原因。
DNA fragments were sequenced by automated fluorescence sequencing.
自动荧光测序法测定acrAB基因扩增产物DNA序列。
Objective: To identify the sequence of the multiple-antibiotic-resistant efflux acrAB gene in Salmonella typhi 275 (a clinically isolated strain) and analyze its structure, amino acid sequence.
目的：伤寒沙门菌275主动外排系统acrAB全基因测序并分析其结构。