Objective To explore the association of genetic polymorphisms of CYP2D6 and UGT1A6 with risks of chronic benzene poisoning.
目的 探讨CYP2D6基因和UGT1A6基因多态性与慢性苯中毒易感性的关系。
No association was observed on the UGT1A10 codon 605 and three UGT1A7 polymorphisms genotype between cases and controls.
为 0.1170.827 (P=0.015)。此外在UGT1A10 codon 693与UGT1A7 codon -57，33，622之间具有负相关顷向，但未达显著意义。
Cirrhosis affectes individual UGT isoform mRNA level. Degree of fibrosis has a significant effect on UGT mRNA expression.
肝硬化可影响肝脏葡萄糖醛酸转移酶同工酶的表达水平；肝纤维化对UGT mRNA的表达有显著的影响。
METHODS: Reverse transcription and polymerase chain reaction and Southern hybridization were used to determine the mRNA levels of five UGT isoforms in hepatic tissues.
应用RT-PCR和Southern杂交技术，观察肝硬化患者肝脏组织中UGT同工酶mRNA表达水平的差异，及肝纤维化对UGT表达水平的影响。
The ancestor species of baculovirus gained antennal-enriched UGT, which evolved to egt gene later.
家蚕的部分UGT基因与转座子元件连锁的基因组结构特点反映了杆状病毒的egt基因可能通过转座子的传递而获得。
Methods:Primary rat hepatocyte cultures and northern blot analysis have been used to determine the mRNA levels of five UGT isoforms in cultured hepatocytes following treatment with bilirubin and bile acids.
应用原始鼠肝细胞培养和Northen斑迹杂交技术，观察胆红素和胆汁酸处理肝细胞前后UGT同工酶mRNA的变化。
KEY WORDS cholelithiasis; Shengqing Capsules; B UGT; cholesterol 7α hdroxylase; gene
关键词］胆结石；升清胶囊； B UGT；胆固醇7α羟化酶；基因
Inflammation grade showed no obvious effect on mRNA expression of most UGT isoforms. CONCLUSION: Cirrhosis affectes individual UGT isoform mRNA level.
肝硬化可影响肝脏葡萄糖醛酸转移酶同工酶的表达水平；肝纤维化对UGT mRNA的表达有显著的影响。
Colonic neoplaslns; Liver; Glucuronosyltransferase; Genes, UGT; Gene expression
结肠肿瘤肝葡糖醛酸基转移酶基因，UGT 基因表达
Significant trend of biliary lithiasis index in patients of liver-ying insufficiency syndrome may be related to decreased expression of B-UGTmRNA in liver, dysfunction of bilirubin glycuronogenesis, increase of biliary MCB, 〓 mRNA hyper-expression in liver and hyper-saturation of bilitary cholesterol.
肝阴不足证患者胆汁成石趋势明显，其原因可能与肝脏B-UGTmRNA低表达，肝脏B-UGT酶活性降低，胆红素的葡萄糖醛酸化障碍，导致胆汁中MCB百分含量增高，以及肝脏〓mRNA过表达导致胆汁胆固醇过饱和有关。
Of the 150 patients screened for KRAS mutations, 26 (17.3%) patients were identified.
本研究中并未发现UGT1A7 基因多型性与KRAS 基因突变的发生具有显著之相关性。
Results Taking cDNA from bone marrow in C57BL/6J mice at 4hr after whole-body irradiation with 7Gy 60 Co -rays as the tester, and the cDNA from the control mice as the driver, the subtracted cDNA library was constructed successfully. After PCR test, 480 clones which have inserted differential cDNA fragments were conserved. The possibly induced genes in bone marrow of C57BL/6J mice at 4hr after whole-body irradiation with 7Gy 60Co y-rays included an unnamed protein, interferon-induced protein with tetratricopeptide repeats 1 (IFIT1), neutrophilic granule protein, 8100 calcium binding protein A8 (S100a8), Hemoglobin alpha, N-methylpurine-DNA glycosylase, cyclin-dependent kinase inhibitor 1A (CDKN1A), heme oxygenase 1 and cytochrome P450, family 2 subfamily e polypeptide 1 (CYP2E1 The possibly repressed genes included chaperonin subunit 3 (CCT3), nucleophosmin 1 (NPM1), N-acetyltransferase 3 (NAT3), prostaglandin-endoperoxide synthase (PTGS1), UDP-glucuronosyltransferase 1 family, member 1 (UGT1A1 Some expressed sequence tags which possibly represented the new radiation-related genes were also separated.
结果成功构建C57BL／6J小鼠受7Gyγ射线照射后4hr的骨髓组织相对未受辐射正常对照的消减cDNA文库，经PCR鉴定后，保存480个含差异表达cDNA片段的单克隆。7Gyγ射线照射后4hr C57BL／6J小鼠骨髓表达可能升高的基因有一未命名蛋白、干扰素诱导蛋白(IFIT1)、嗜中性粒蛋白、钙结合蛋白(S100a8)、珠蛋白α链(Hba1)、MPG、CDKN1A(周期蛋白依赖的蛋白激酶抑制蛋白)、CAT、HO1和CYP2E1(细胞色素P450家族成员)；表达可能降低的有CCT3(分子伴侣3)、NAT3(N-乙酰转移酶3)、NPM1、PTGS1(前列腺素内过氧化物合酶)、UGT1A1；同时分离了可能代表辐射相关新基因的EST序列。
The activity of liver UGT (UDP-Glucuronyl-Transferase) of D300 was higher than F300 and there was no difference between two groups in GST (Glutathione-S-Transferase) activity.
餵食炸油之天竺鼠肝中UDP-Glucuronyl-Transferase活性高於新鲜油组，Glutathione S-Transferase活性於两组间则没有差异。
Methods: Primary rat hepatocyte cultures and northern blot analysis have been used to determine the mRNA levels of five UGT isoforms in cultured hepatocytes following treatment with bilirubin and bile acids.
方法：应用原始鼠肝细胞培养和Northen斑迹杂交技术，观察胆红素和胆汁酸处理肝细胞前后UGT同工酶mRNA的变化。
Conjugation Reaction of UGTs and N - glucuronic Acid
UGT酶与N-萄糖醛酸结合反应
Conclusions The expression of UGT can be regulated by ethanol and isopentanol. As a result, chronic alcohol consumption may modify the metabolism of numerous endogenous and exogenous compounds, in particular some drugs, which are substrates of these UGT isoenzymes.
结论乙醇和异戊基丙醇可调节UGT的表达，长期酒精摄入可干扰作为这些UGT同工酶底物的内源性和外源性物质的代谢，特别是药物的代谢。
Objective To investigate whether ethanol and isopentanol could modulate the drug metabolism by regulating uridine diphosphate glucuronosyltransferase (UGT) expression in rat livers and cultured rat hepatocytes.
目的探讨乙醇和异戊基丙醇是否可以调节尿苷二磷酸葡萄糖醛酸基转移酶（UGT）的表达来影响药物的代谢。
The effects of three different varieties of green tea extracts (CGT, NGT and UGT, from China, Japan, and Kenya), on the foaming and rheological, and thermal properties of whey proteins were investigated in this paper.
本文选用三种不同的绿茶提取物（CGT、NGT和UGT，分别来自中国、日本和肯尼亚），探讨绿茶提取物对乳清蛋白的发泡特性、流变特性和热力学特性的影响。
METHOD: The structure and function of UGTs, gene polymorphism, expression specification in tissues, scope of drug glucuronidation and factors affecting drug glucuronidation in humans were summarized.
方法：从UGTs的结构和作用，UGTs的基因结构和基因多态性，UGTs的组织分布，药物在人体内葡醛酸结合反应的范围，影响UGT活性变化的因素等方面分别进行总结。
Objective: To investigate the direct effects of sex hormones, growth hormone, thyroid hormones and dexamethasone on the regulation of UDP glucuronosyltransferase (UGT).
目的：探讨性激素、促生长素、甲状腺素和糖皮质激素对UDP葡萄糖醛酸基转移酶（UGT）表达的调节作用。