Results Lung injury was markedly reduced in tetramethylpyrazine-treated group and tetramethylpyrazine significantly attenuated NF-κB activation of BAL macrophages. PLA 2, TNFα, IL-1, IL-6levels of serum and lung tissue were decreased significantly; 24hour-mortality was reduced obviously by tetramˉethylpyrazine.
结果 川芎嗪能明显降低AHNP大鼠24h死亡率；减轻肺组织及胰腺的病理性损伤；降低血中、肺组织中及腹水中PLA 2 活性；减少腹水生成量；降低血中、肺组织中TNFα、IL-1、IL-6水平；显著降低肺泡灌洗液巨噬细胞NF-κB活性。
Thirty-six male Sprague-Dawley rats were randomly divided into four groups: Normal, Model, SIN and TWP group. 24h urine protein was determined with the trichloroacetic acid turbidimetry. SerumTP, Alb, TC, TG, HDL, LDL, BUN, Scr were assayed with the automaticbiochemistry analyzer. Each group of the mesangiu area and the membrane cell and the extracellular matrix were observed with light microscope, electron microscope. The expression of TNF-αwas observed with the immunohistochemical staining and reverse transcription polymerase chain reaction. The sectionof HE, Masson, PAS staining and immunohisto- chemistry staining was analyzed with the pathology image analysis system.
选用SD大鼠(雄性，体重150±20g)38只，按体重随机分为正常组、模型组、青藤碱组、雷公藤多甙组，除正常组外，其他三组均采用免疫学方法复制系膜增生性肾小球肾炎模型，应用三氯乙酸法测定各组大鼠24h尿蛋白的含量，全自动生化分析仪检测各组大鼠血清总蛋白、白蛋白、总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白、尿素氮、肌酐，光镜、电镜下观察各组大鼠肾小球系膜区情况及肾小球系膜细胞和细胞外基质积聚变化，采用免疫组织化学法和逆转录-多聚酶链反应技术，检测各组大鼠肾组织肿瘤坏死因子-α蛋白及TNF-αmRNA的表达，并用病理图像分析系统对肾组织常规病理及免疫组织化学染色结果进行半定量分析。
Matrix metallo-proteinase-9 (MMP-9) can degrade extracellular matrix, distroy vessel basemembrane and induce edema formation. Tumor necrosis factor- a may act as an operator in ischemic inflammation. It can also affect the edema formation.
基质金属蛋白酶9(MMP-9)能降解细胞外基质，破坏血管基底膜，加重血管源性脑水肿的形成；肿瘤坏死因子在缺血后炎症反应中的启动作用已被普遍认同，同时TNF-α亦参与了脑缺血后水肿的形成，MMP-9与TNF-α在脑缺血损伤过程中的相互作用值得重视。
Objective To investigate the protective effec t of tumor necro sis factor - alpha on sensory n eurons after nerve injury.
目的 探讨肿瘤坏死因子-αtumor necrosis factor alpha，TNF -α）对周围神经损伤后感觉神经元的保护作用。
Methods: The male Wistar rats were modeled to AA with Complete Freund's adjuvant, then treated by the deer tendons collagen, to observe the toes swelling degree, weight, serum levels of IL-lβ and TNF-a, content of MDA and vitality of SOD in serum.
以完全弗氏佐剂诱导的Wistar雄性大鼠佐剂性关节炎为研究对象，观察经鹿筋胶原治疗前后的足趾肿胀度、体重、血清中的IL-lβ和TNF-a炎性细胞因子、血清中的MDA含量和SOD活力。
Objective To observe changes of cytokine tumor necrosis factor-α, interleukin-1β(IL-1β) after cardiopulmonary cerebral resuscitation rats.
目的 探讨窒息至心脏骤停大鼠复苏后心脑IL-1β和TNF-α的变化。
TNF receptor on tumor cellular membrane received ligand sign, made tumor cell apoptosis with death receptor pathway; (2) cytotoxicity directly to tumor cell.
肿瘤细胞膜TNF受体收到配体的信号后，通过死亡受体途径使肿瘤细胞发生凋亡；(2)对肿瘤细胞的直接细胞毒性。
Methods:66 cases of cerebral hemorrhage in 72h were randomly divided into treatment group(35 cases)and control group(31 cases).
选择72小时内的重症脑梗死病人66例，随机分为对照组31例和治疗组35例，对照组采用常规治疗，治疗组加用必存15mg/d治疗10天，在治疗前后腰穿取脑脊液，用ELESA法检测脑脊液中TNF-α、IL-6，并在3周后进行神经功能缺损评分。
Similar changes in adenosine levels were found in 2 other models of heart failure, mice overexpressing calsequestrin and mice after chronic pressure overload, suggesting that the changes in adenosine-AR signaling were secondary to myocardial dysfunction rather than to TNF overexpression.
在其它2种心衰模型（过表达隐钙素的老鼠和慢性压力符合过大的老鼠）的腺苷水平也发现相似的变化，说明腺苷-AR信号的变化是继发于心肌功能异常的，而不是继发于TNF的过表达。
Similar changes in adenosine leels were found in 2 other models of heart failure, mice oerexpressing calsequestrin and mice after chronic pressure oerload, suggesting that the changes in adenosine-AR signaling were secondary to myocardial dysfunction rather than to TNF oerexpression.
在其它2种心衰模型（过表达隐钙素的老鼠和慢性压力符合过大的老鼠）的腺苷水平也发现相似的变化，说明腺苷-AR信号的变化是继发于心肌功能异常的，而不是继发于TNF的过表达。
Methods: The number of CD4+T reg was detected among by use of flow cytometry. The content of serum IL 10, TNF α and TGF β were determined by enzymelinked immunosorbent assay.
采用流式细胞术检测外周血CD4+T reg数量，采用酶联免疫法测定血清IL 10、TNF α、TGF β水平。
Result: The contents of IL-8, TNF-α in the peripheral blood and peritoneal fluid of model group were higher than that of the blank group; The quality of allotopia growth intima tissue, the quantity of macrophage in peritoneal fluid and the contents of IL-8, TNF-αin the Xianggui pill group and Danazol group were all lower than those of the model group; but there was no significont difference of each target between the Xianggui pill group and Danazol group.
结果：模型组外周血、腹腔液IL-8，TNF-α含量均高于空白对照组；香桂丸组及丹那唑组异位种植内膜组织质量、腹腔液巨噬细胞数量及IL-8，TNF-α含量均低于模型组；但香桂丸组与丹那唑组间各项指标差异不显著。
ZYC can function regulating the endocrine affecting the expression of the TNF-α coherently in center and ovary to adjust genital gland and promote the mature and ovulation of follicular.
助孕胶囊能够通过调整内分泌及影响卵巢肿瘤坏死因子α的表达，在中枢及卵巢局部协调发挥作用，从而调整性腺功能，促进卵泡的发育成熟及排卵。
IL-8 and TNF-α play an important role during the process of intestinal endotoxemia caused lung damage, the method of Tongfu will protect the lung from damage.
结论IL-8、TNF-α在肠源性肺损伤过程中起重要作用，通腑法对损伤肺组织起保护作用。
There is no significant correlation between the expression of TNF-a in placenta and the insulin resistance.
2胎盘TNF-α的表达与GDM及其胰岛素抵抗的关系不明显。
Objective: Biotherapy has been the forth tumor treatment methods besides operation, irridation and chemotherapy. Tumor necrosis factor-alpha is one of the earliest cytokins used in clinical care, but its use was limited because of its wide and intensive side-effects.
目的：生物治疗已成为继手术、放疗、化疗后第四大肿瘤治疗手段，肿瘤坏死因子α(Tumor necrosis factor-alpha，TNF-α)是最早应用于临床的生物因子之一，但由于其广泛而严重的不良反应限制了肿瘤坏死因子α的进一步应用。
RESULTS: Pre- or posttreatment with C-PC (30 or 50 mg/kg, IP)significantly attenuated carrageenan-induced inflammatory nociceptionand the induction of iNOS and COX-2 at the late phase, (4 h)accompanied by an inhibition of the formation of TNF-, prostaglandinE2, nitrate and myeloperoxidase activity.
结果：在角叉藻聚糖诱导前或诱导后使用 C-PC (30 or 50 mg/kg，IP)可明显减弱炎症伤害性感受以及后期（4小时） iNOS 和 COX-2的诱导作用，并抑制 TNF-、前列腺素 E2、硝酸酯的形成及髓过氧化物酶的活性。
3Monitoring IL-1β、TNF-a phlegmasia cell factor of CFA postimmune ratss blood with radio-immunity, and analyze it.
4CFA免疫后用ELISA法检测血中的IFN-r，IL-4水平，并将其比值与Th1／Th2进行相关分析。
TNF-α that activated retinal glial cells may play an important role in glaucomatous retinal ganglion cell damage.
在慢性高眼压情况中，活化的视网膜胶质细胞来源的TNF-α可能在神经节细胞损伤中发挥重要作用。
H2 cells stimulate the humoral immunity, the secretion of IL-4 can promote B-cell proliferation and induce the formation of antibodies, particularly IgE production, the main TH1 cells secreted IFN-γ.IL-2 and TNF-a, TH1 to remove the source of infection for the body, including hidden in the bacterial source of infection, the group observed that the level of IL-4 was significantly higher than that of IFN-γlevels before treatment is higher than that trend, the ratio compared with the control group IFN-/γIL-4 reduce body for the performance of state TH2 advantage of the trend, relief periods when IFN-r level lower than the control group, the level of IL-4 was significantly lower than the control group, after treatment 1FN-γ/IL-4 ratio compared with the control group, IFN-γTH1 activity and can improve the level, so the body for the performance advantages of TH1 state.
h2细胞刺激体液免疫，分泌的IL-4能促进B细胞的增殖和诱导抗体的产生，尤其是IgE的产生，TH1细胞主要分泌IFN-γ，IL-2和肿瘤死因子-α，THI有利于促进机体清除感染源，包括隐藏在细胞内的感染源，本组观察到IL-4水平治疗前明显高于对照组，IFN-γ水平治疗前有高于对照组的趋势，使IFN-γ／IL-4比值较对照组减低，机体表现为TH2优势状态趋势，缓解期时IFN-γ水平低于对照组，IL-4水平明显低于对照组，IFN-γ／IL-4比值治疗后较对照组高，所以机体表现为TH1优势状态。