In conclusions, (1) IGF-I and EGF can improve in vitro maturation of porcine oocyte, and the optimum concentration is 10 ng/ml and 50 ng/ml; (2)FSH is more efficient for in vitro maturation of porcine oocyte than hMG; (3) The superior electronic activation parameter for porcine oocyte is:80 v/mm, 30 μs~50μs.
以上结果表明：(1)IGF-Ⅰ和EGF对猪卵母细胞的体外成熟均有促进作用，其添加的适宜浓度分别为10ng／ml与50ng／ml；(2)添加FSH的猪卵母细胞成熟培养效果优于hMG；(3)猪卵母细胞的适宜电激活参数为：80v／mm，30μs—50μs。
In this study, we chose hUBF HMG box 5 as a model and mainly used NMR method in combination with native-state hydrogen/deuterium exchange to study the folding characteristics of the HMG box domain.
本课题中我们选用了hUBF HMG box5蛋白为模型，主要采用核磁和自然态下氢氘交换相结合的方法研究了HMG box这一类蛋白结构域的折叠特性。
Heavy machine guns were mainly locally-made 1924 water-cooled Maxim guns, from German blueprints. On average every battalion would get one HMG. The standard sidearm was the 7.63 mm Mauser M1932 semi-automatic pistol
中国军队配备的重机枪则主要是根据德国图纸制造出的水冷式马克逊机枪，平均每个营可以配上一挺，一般步兵的标准配置则是7.63毫米 M1932型半自动毛瑟手枪。
Objective To observe the effect of Erzhitiabjing decoction combined with HMG in treating anovulation and infertility, and to explore its effective mechanism.
目的：观察二至调经方联合尿促性素治疗排卵障碍性不孕症的疗效，并探讨其作用机理。
Genes, including metabolism related genes （PDK4）, and caveolin 2, metallo thionein 1B, were up-regulated in both obese and obese diabetic patients, while 8 genes, including key enzymes in lipid synthesis, such as HMG-CoA synthase, fatty acid synthase and stearoyl-CoA desaturase, were down-regulated in both groups.
这些基因中有77个在两组中均上调，其中包括与代谢有关的基因，如丙酮酸脱氢酶激酶4（PDK4）以及窖蛋白、金属硫因蛋白等；8个基因在两组中均下调，其中包括脂肪合成途径中的关键酶，如3-羟基-3-甲基戊二酸单酰辅酶A合成酶、脂肪酸合成酶及硬脂酰辅酶A脱氢酶。
As a model terpenoid, the ginsenoside is one of Panax ginseng's main effective components.
人参皂苷是人参的主要有效成分之一，属典型的萜类化合物。本文对萜类生物合成途径及HMG-CoA还原酶进行了综述。
Results HMG CoA reductase allelic frequencies of A, a were 0.519, 0.481; 0.440, 0.560 in CHD group and control group respectively....
结果 Scr F1多态位点等位基因 A、a频率在 CHD组和正常对照组分别为 0 。5 19、0 。4 81和 0 。4 4 0、
Medical experts theorize that it may also inhibit activity of the cholesterol production enzyme HMG CoA Reductase to balance LDL cholesterol and trigylceride production in the liver for cardiovascular support.
医学专家推论，它也可以抑制胆固醇活性的酶生产戊二酰辅酶A还原酶平衡低密度脂蛋白胆固醇和trigylceride生产肝脏心血管支持。
Methods HMG CoA reductase genotyping was performed using polymerase chain reaction restriction fragment polymorphism.
用聚合酶链反应-限制性片段长度多态性方法分析 HMG- Co A还原酶基因第 2内含子区 Scr F1酶切多态性。
Cholesterol synthesis is an important part in its metabolism and it is regulated by feedback inhibition. 3-hydroxy-3-methlglutaryl coenzyme A reductase, which is regulated by transcription and protein degradation, catalyzes the reduction of HMG CoA to mevalonate, a rate-limiting step in the synthesis of cholesterol.
胆固醇的起始性合成途径是其代谢的重要组成，该途径受细胞中胆固醇的负反馈调控。3-羟基-3-甲基戊二酰辅酶A还原酶催化HMGCoA生成甲羟戊酸，是胆固醇合成途径中关键的限速步骤，它在转录和蛋白水平受甾醇的负反馈调控，其中甾醇促进的HMGCR的蛋白酶体降解是胆固醇合成途径关键的反馈调控步骤。
Long term medication of statin, a HMG CoA reductase inhibitor, have been proven effective in reducing LDL-C levels and improving the endothelial dysfunction in adult patients of atherosclerosis.
Statins，hydroxymethylglutaryl coenzyme A 还原酶抑制剂，已经被证实不仅可以降低LDL-C，同时可以改善成人的血管粥状硬化和血管内膜的功能异常。
Medical experts theorize this is because artichoke extract inhibits the activity of the enzyme HMG CoA Reductase to decrease the amount of cholesterol made by your liver.
医学专家的说法，这是因为洋蓟提取活性酶抑制辅酶还原酶减少胆固醇合成量。
AIM To investigate the effect of OX-LDL and HMG- CoA reductase inhibitors simvastatin on PKC activity and cytosolic free Ca2+ in cultured human monocy tes.
目的探讨OX-LDL及HMG-CoA还原酶抑制剂辛伐他汀对人单核细胞表达蛋白激酶C活性和胞浆内游离钙(［Ca2+］i)浓度的影响。
These results suggest that extract from rape pollen enriched in alpha-linolenic acid are effectively in decreasing the levels of lipid in plasma and hepatic tissue to various extent compared to the common diet. This is possibly due to decreasing activity of HMG-CoA reductase and indirectly increasing in DHA concentration of hepatic tissue. The extract also decrease plasma level of IL-2 to regulate atherosclerosis.
由以上实验结果可初步认为：以亚麻酸为主要成分的油菜花粉超临界CO2萃取物能够通过抑制肝脏HMG-CoA还原酶活性来调节胆固醇的代谢，降低apoE小鼠血清和肝脏中TC的含量，同时影响血清中IL-2的含量来影响动脉粥样硬化。
It is mediated by the cytokine TGF-β, Rho-dependent contractility, and cell–matrix interactions in an interdependent fashion.
HMG-CoA还原酶抑制剂已被证明可以抑制Rho家族小鸟苷三磷酸酶的
Statins is HMG—CoA reductase inhibitor. In the recent investigations, statins has important functions in the prevention and therapy of the stroke. This article overviewed the medical evidence of statins in prevention and therapy of stroke and analyzed mechanisms including descendens blood fat. stabilization atherosclerotic plaque. antiinflammatory. hypotension
他汀类药物是3羟基-3-甲基戊二酰辅酶A(HMG一CoA还原酶抑制剂)，近年来研究发现，在防治卒中中起重要作用，本文综述了他汀类药物防治卒中的医学证据，并分析了其中的作用机理，包括降低血脂、稳定动脉斑块、抗炎、降低血压、抑制血小板的粘附与聚集等作用。
Drugs of beta-hydroxy-beta-methylglutaryl coenzyme A reductase inhibitors family are usually used as a very effective lipid-lowering preparations but they simultaneously block biosynthesis of both cholesterol and ubiquinone Q10, which is an intermediate electron carrier in the mitochondrial respiratory chain. It is known that reduced form of ubiquinone Q10 acts in the human LDL as very effective natural antioxidant.
HMG-CoA还原酶抑制剂是非常有效的降脂药物，但它同时抑制胆固醇和辅酶Q的生物合成，而其中辅酶Q是线粒体呼吸链中的中间电子载体，其还原形式在人LDL中是有效的天然抗氧化剂。
TCM199 was used as cultule medium to discuss the affection of HMG as hormone on porcine oocytes maturation in vitro and development. At the same time effects of EGF, TGF-a separation or combination on porcine oocytes IVM and development were studied to establish better culture system.
以TCM199为基础培养基，HMG为激素，探讨了HMG在猪卵母细胞体外成熟和发育中的影响；同时对EGF和TGF-α单独或联合使用对猪卵母细胞IVM及发育的影响进行了研究，以确立猪卵母细胞IVM较好的培养体系。
In the first part, it was reported that the progress of studies on inhibitors of cholesterol synthetic enzymes including HMG-CoA synthetase, HMG-CoA reductase, squalene synthetase, squalene cyclase and acyl-CoA: cholesterol- acryltransferase. Then, the screening model of inhibitors of cholesterol synthetic enzymes in vitro was simply introduced including screening results. The main point focused on the studies of secondary metabolites of the strain SIPI-8926 and strain SIPI-8917. Three bioactive compounds were isolated from the strain SIPI-8926, named as SIPI-8926-Ⅱ, Ⅲ and Ⅳ. By the analyses of chemico-physical properties, MS, UV, IR and NMR etc. spectra, the structures of three compounds were elucidated and were identical with those of Daidzein, N-acetyltyramine and soyasapogenol B respectively. In bioactivities, Ⅲ and Ⅳ showed less inhibitory activity on cholesterol synthetic enzymes in vitro, but Ⅱ exhibited good inhibitory activity, and all have not antibacterial activities. More over, in the concentration of 0.5mM-5mM, three compounds all have inhibitory activities on thrombin 〓 factor and inhibitory activity on nematode under 10mM.
在第一部分，首先介绍微生物来源胆固醇生物合成酶抑制剂的研究进展，主要包括HMG-CoA合成酶、还原酶、角鲨烯合成酶、角鲨烯环氧化酶和酰基辅酶A：胆固醇酰基转移酶等酶抑制剂的研究进展；其次简单说明本实验室建立的胆固醇生物合成酶抑制剂的体外筛选模型，及筛选结果；再重点介绍阳性菌株SIPI-8917和8926代谢产物的研究，从SIPI-8926菌株中分离出3个活性化合物，分别命名为：SIPI-8926-Ⅱ、Ⅲ和Ⅳ，通过理化性质、质谱、紫外、红外和NMR图谱的分析，确定3个化合物的结构，其中Ⅱ为异黄酮化合物、Ⅲ为酰胺化合物、Ⅳ为三萜皂甙元，分别与文献报道的Daidzein、N-Acetyltyramine和Soyasapogenol B的结构一致；生物活性研究发现，Ⅲ和Ⅳ化合物在体外胆固醇生物合成酶系统中抑制活性不高，而Ⅱ的抑制活性较强，体外均无明显的抗菌活性，在0.5mM-5mM浓度下产生明显的抑制凝血ⅩⅢ因子活性，另外在高浓度（10mM）下均具有抑制线虫的活性，并以Ⅱ的活性为最强。
It supports the glucocorticoid is required for fat buildup of BAT. Leptin, the other factor for energy balance, was severely low in circulation of Cyp11a1-/-mice. Further, triglycerides in the serum were markedly lower in Cyp11a1-/-mice, but triglycerides in the livers were enhanced that results lipid droplets accumulation. The hepatic gene expression of fatty acids catabolic enzyme, acyl-CoA oxidase, was elevated in Cyp11a1-/-mice. The mRNA of the genes involved in gluconeogenesis, glucose-6 phosphotase and phosphoenopyruvate carboxykinase, however, were not changed in 3-day old Cyp11a1-/- livers. This report demonstrates that Cyp11a1-/- mice have energy problems caused by hypoglycemia as well as shortage of glycogen and lipid storage. tc Table of Content Abstract in Chinese..
另外，在脂肪囤积与分布方面，此种小鼠背部的棕色脂肪组织明显的减少，利用组织切片来看油脂的囤积，发现在棕色组织中的油滴较小；在肝脏中，此种小鼠有三酸甘油脂的脂肪囤积，而血液中的三酸甘油脂的含量却下降，因此推测可能因为缺乏醣皮质素类固醇贺尔蒙，而影响肝脏能量代谢的问题，利用基因晶片及北方墨染法分析一些参与在醣类与脂肪代谢中的基因表现，发现Cyp11a1剔除小鼠的肝脏中，参与在糖原异生作用的酵素：葡萄糖-6-磷酸脢（glucose-6-phosphatase）与（phosphoenolpyruvate carboxykinase），此两种基因的RNA的量并无明显的改变，醣解作用中的酵素：丙酮酸激脢，此种基因的RNA表现量降低；关於脂类代谢方面，参与在长链脂肪酸氧化系统中的酵素：醯基辅脢A氧化脢(acyl-CoA oxidase)，此种基因的RNA表现量增加，这样的结果推测Cyp11a1剔除小鼠的肝脏中脂肪的代谢增加而糖解作用减少；此外，在Cyp11a1剔除小鼠的肝脏中当中，意外的发现到HMG CoA synthase基因的表现量下降，表示胆固醇的生合成也可能受到了抑制。