In water solution with pH5.0-9.0, the CdS nanoparticles can react with a kind of anthracycline anticancer drugs such as MXT, DNR and EPI to form the larger aggregates by virtue of electrostatic attraction and hydrophobic force. The aggregates arouse Resonance Rayleigh scttaring instancing greatly, and the new RRS spectra appeared. The maximum RRS peaks are at 292nm for MXT system, 285nm for DNR system and315nm for EPI system, respectively.
在pH=5.0~9.0的水溶液中，硫化镉纳米微粒与蒽环类抗生素米托蒽酿表柔比星和柔红霉素凭借静电引力及疏水作用力结合，形成粒径更大的聚集体，导致共振瑞利散射的增强并产生新的RRS光谱，最大的RRS峰位于292nm、285nm和315nm。
At the same time, the Second-order Scattering and Frequency-double Scattering are also enhanced obviously. The maximum SOS peaks are at540nm for MXT system, 560nm for EPI system and DNR system, but their maximum FDS peak are at320nm for EPI system, 330 nm for DNR system and 330 nm for MXT system, separately.
与此同时还观察到二级散射和倍频散射强度明显提高其最大SOS峰位于540nm和560nm，而最大的FDS峰分别位于335nm、320nm和330nm。
He CR rate is much higher in TOPOⅡα positive group than those in negative group; ⑹ The drug sensitivity test is correlated with outcome of chemotherapy with an overall predictive rate of 86.67%, 75%, a positive predictive rate of 92.31%, 83.33%, a negative predictive rate of 50%, 50% in AML and CML; ⑺ CSA significantly potentate the cytotoxicity of DNR, MXT, VCR and VP-16 to K562/A02 resistance cell line which overexpress PGP, and MXT to the leukemic cells of patient whose leukemic cell overexpress PGP; ⑻ BSO did not increase the depressive rate of anthracycline and alkaliod to PGP overexpressed K562/A02 cell line and the leukemic cells which overexpress PGP, MRP1 and GSH, But significantly improve the depressive rate of AS2O3 and AS4S to leukemic cells.
OPOⅡα阳性白血病组的CR率为93.75%，明显高于阴性组的58.33%；⑹ CSA可以明显增加柔红霉素、米托蒽醌、长春新碱和足叶乙甙对PGP表达阳性K562/A02耐药细胞及患者白血病细胞的细胞毒性作用，但不影响对MRP1、GSH高表达患者白血病细胞的毒性作用；⑺ BSO不增加蒽环类、长春碱类、表鬼臼类等天然药物对表达不同耐药蛋白白血病细胞的抑制率，但明显增加了AS2O3和AS4S4对白血病细胞的抑制率。
Leukemia cell lines were treated with DNR and etopside. Cell's ability of prolification were analyzed by MTT methods.
分别用DNR和VP-16对白血病细胞系进行药物处理，通过MTT的方法检测药物对细胞系的增殖能力的影响。
Results Two shRNA plasmids targeting mdr1 mRNA were constructed and cloned. Two mdr1-targeted shRNA could down-regulate mdr1 mRNA expressions with 89.74% and 87.18% respectively, almost completely down-regulate the P-gp expression. The intracellular DNR increased after RNAi treating. The daunorubicin efflux ratio at 60min were 13.16% and 22.02%, compared with control 40.44%, 45.31%, P.05. MTT test demonstrated the relative reversing efficiencies to doxorubicin were 84.36% and 76.69% respectively.
结果 构建了二条针对mdr1基因的shRNA真核表达载体，分别下调mdr1 mRNA的表达89.74%和87.18%，降低细胞膜P-gp表达，使膜外泵功能明显下降，柔红霉素在细胞内贮留明显增多，60min时柔红泵出率为13.16%、22.02%，对照组为40.44%、45.31%，对阿霉素药物敏感性的相对逆转率为84.36%和76.69%。
Objective:To study the cytotoxic activity of DNR and VCR on HL-60 cell line in vitro.
目的 ：观察柔红霉素、长春新碱联合应用在体外对人急性髓系白血病细胞株(HL—60)的相互作用。
Methods DNR subcellular disposition was studied by confocal scanning laser microscopy, fluorescent methods, MTT and RT-PCR. The effects of verapamil, brefeldin A, chloroquine were also examined.
采用共聚焦激光扫描显微镜观察、荧光染色、MTT、逆转录-聚合酶链反应等方法研究柔红霉素在HL-60/ADR细胞内的分布及与耐药的关系，以及维拉帕米、布雷菲尔得菌素、氯喹对细胞内DNR异常分布的影响。
Results In the drug-sensitive cell line HL-60/S DNR fluorscence distributed evenly in the nucleus and cytoplasm, while in the resistant cell line DNR distributed in a punctate pattern in the cytoplasm and was reduced in the nucleus. Verapamil, brefeldin A, but not chlorquine could recover the intracellular distribution of DNR from punctate to even in the resistant cell line.
结果 与DNR在HL-60细胞核、胞浆均匀分布不同，在HL-60/ADR，DNR呈点棘状分布于细胞浆外周区，核内DNR荧光很少；维拉帕米、布雷菲尔得菌素可逆转DNR在HL-60/ADR的异常分布，而氯喹无此作用。
The rate constant of catalytic reaction K〓 is 〓 in the 0.05mol/L 〓(pH6.82) solution.
求得在0.05mol/L 〓溶液（pH6.82）中，DNR催化反应的速率常数K〓为〓。
I show that hypomorphic mutations of the essential dNR1 gene disrupt olfactory learning, and can be rescued by wild-type transgenes.
利用弱显型的 dNR1突变株，在同型合子的 dNR1突变株中轻微的抑制dNR1表现。在行为研究上，则观察到其嗅觉学习的缺陷。
Since the proposed method combines the global search ability of FGA and the advantages of positive feedback mechanism of ACSA, thereby improve optimization efficiency of DNR based on FGA.
由于提出的方法结合了遗传算法的全局搜索能力和蚁群算法的正反馈机制的优点，因此提高了模糊遗传算法进行配电网络重构的寻优效率。
Objective To observe the clinical effect of Daurorubicin (DNR) preventing the posterior capsule opacification (PCO).
目的观察柔红霉素预防后囊膜混浊的临床效果。
The results showed that TTD could significantly potentiate the toxicities of DNR and HHT in drug-resistant leukemic cell lines (K562/A02, K562/HHT), the IC50 values decreased 15.8 bold and 19.1 fold respectively (P0.05);
结果TTD可明显提高DNR及HHT对耐药细胞（K562／A02，K562／HHT）的毒性作用，IC50值分别下降15.8及19.1倍（P＜0.05）；
Treatment of 192 Cases with Chronic Hypertrophic Rhinitis by DNR
数控热凝治疗机治疗慢性肥厚性鼻炎192例
Results: Compared with DNR group, the shedded cardiomyocytes and the cell debris of DNR + QUE group was decreased, the content of LDH and MDA lowered (P < 0.05) and the activity of SOD increased (P < 0.05) with a dose-effect correlation.
结果：与DNR组比，DNR+QUE组脱落细胞减少，细胞碎片减少，LDH和MDA含量降低（P<0.05），SOD活性增高（P<0.05），且有剂量效应关系。
But in 10 DNA treated eyes, be-cause of severe inflammatory response such as comeal edema and severe fibrous exudate in anterior chamber, the fundus and ERG could not be studied.
而10只注入DNR眼出现严重的内皮性角膜水肿混浊，前房大量纤维索性渗出特等明显的炎性反应眼底及视网膜电图无法检查。
Conclusion Besides inducing apoptosis and restraining proliferation of leukemic cells, ATRA and DNR exerted their anti-leukemia effects by reducing angiogenesis via reduction of angiogenic reaction stimulating signals.
结论这两种化疗药物除了可以诱导白血病细胞分化或抑制白血病细胞生长外，还可以通过抑制促血管新生，使新生血管减少，以发挥抗白血病的效应。
Conclusion: The results indicated that there was cross resistance between DNR and Harr for AML cells.
结论：白血病细胞对上述两种药物有交叉耐药性。
Verapamil increased the intracellular drug accumulation, and then obviously reversed the drug resistance to DNR, VCR, MIT, HHT, and VP 16 in K562/D cells, but not in the sensitive cells (K562/S).
异搏定使K562/D细胞内药物积聚增加，明显地逆转了K562/D细胞对DNR、VCR、MIT、HHT、VP-16的耐药性，而对敏感细胞K562/S的耐药性无影响。
Anthracycline antibiotics such as daunomycin, epirubicin, mitoxantrone and congo red systems;
蒽环类抗生素柔红霉素（DNR）、表柔比星（EPI）、米托葸醌（MXT）与刚果红（CR）相互作用的反应体系；