Do you have any ti ckets avai l abl e for that date?
你们有那天的票吗?
We regret that the goods you i nqui re about are not avai l abl e.
很遗憾,你们所询的货物现在无货。
Objective To investigate the effect of bcr abl fusion gene on CML cell apoptosis.
目的研究bcrabl融合基因在慢性粒细胞白血病细胞凋亡调控中的作用。
ABL and BCR, which are located on chromosomes 9 and 22, respectively, are normal genes whose function is still unknown.
ABL和BCR都是正常基因,分别位于第9和22号染色体上,目前对它们的功能尚不清楚。
Additional studies were needed to evalaute the value of two types of bcr/abl mRNA.
两种不同的bcr/abl mRNA的临床意义尚需进一步探讨。
We synthesized 18 ploy ASON fragment and 18 ploy non-senseASON fragment, according to the 18 nucleotides sequence astarget gene of bcr/abl fuse gene and studied the inhibition effect ofASON to K562 cell-line, The results showed that ASON hasdifferent inhibition rate on cell proliferation at concentration of3.5~30.0μmol/L.
我们根据bcr/abl基因的不同类型的cDNA序列分析,以bcr/ablmRNA融合区的18个核苷酸为作用靶序列,人工合成了18聚ASON片段,同时合成18聚无义ASON片段,进行了ASON对CML细胞株K562细胞的抑制作用的研究。
Methods Eighteen nucleotides were used as target genes in bcr/abl mRNA mixed area, by different bcr/abl cDNA sequence type analysis, 18 pdy ASON fragments and 18 poly non-sense ASON fragments for special sequence control were synthesized.
根据bcr/abl基因类型(b3/a2)的cDNA序列分析,以其 mRNA融合区的18个核苷酸为作用靶序列,人工合成了18聚ASON片段,同时合成18聚无义ASON片段,作为序列特异性对照。
By set a timet and a deadline, you will be abl to track your progress to achiev the resolut you desire.
制定时间表和期限,向目标迈进的过程中,就跟踪自己的进度。
And Ericsson China Ltd., a unit of Sweden's Telefon ABL. M. Ericsson, opened a Beijing training center in mid-1995 to hone22 employees'managerial and technical skills.
而爱立信中国股份有限公司——瑞典telefonab.l.mericssion的一个部门于1995年年中开办了一所北京培训中心,以提高员工的管理和技术能力。
Whe n I got back to my office, my boast was that I had been abl e to bond with events before they were on TV.
我一回到办公室,便开始自吹自擂,说我赶在它们上电视之前就与新闻事件先联结上了。
I believe that I can fulfill the requirements in your company. I hope you will be abl
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I shall be abl to call for an interview at your conveni and shall be abl to suppli ani necessari or exampl of my previou work.
随时都可晋见,只要阁下时间方便。并随时提供我过去工作情况的所有资料。
Construction of serial bcr-abl specific ribozymes vectors:Firstly, 3hammerhead ribozymes specific to -29bp, -1bp and +15bp of bcr-abl fusionpoint were designed and synthesized according to bcr-abl cDNA. After generecombination, a series of in vitro transcription vectors for ribozymes and atriple-unit ribozymes retroviral vector pDoR-RZ123 were constructed.
bcr-abl 系列核酶载体的构建及鉴定根据bcr-abl融合基因cDNA序列,分别针对融合位点上游-29bp,-1bp及下游+15bp设计3个锤头状核酶RZ1、RZ2及RZ3,并通过基因重组的方法将其顺序定向克隆入改建的pDES载体中,构建系列核酶体外转录载体及三核酶逆转录病毒载体pDoR-RZ123。
We also examined whether this model recreated the cellular phenotype of CML by assessing cell adhesion, cell migration, cell proliferation and cell survival.
采用细胞免疫组化测定了p210BCR/ABL在CD34+细胞中的表达;细胞粘附、迁移实验进行模型鉴定;FACS法测定了p210BCR/ABL转导及对照CD34+细胞p27kip和MDR-1 Pgp的表达。
AIM To investigate the effect of bcr-abl gene im-munization on the chronic myelogenous leukemiaand explore the feasibility of this fusion gene immunization in CML gene therapy.
目的 研究bcr-abl融合基因免疫在慢性髓系白血病(chronic myelogenous leukemia CML)中的作用以及探讨CML基因免疫治疗的可行性。
These findings provide the first evidence that c-Abl forms homodimers and indicate that homodimerization can contribute to the regulation of c-Abl activity.
这些结果首先证实了c-Abl在细胞内可以相互形成同源二聚体,并暗示着二聚体的形成可能影响着c-Abl活性的调节。
Results The median value of bcr-abl and bcr-abl/abl ratio were (11542±5106) copies/μg total RNA and (10.58±5.12)% at chronic phase, (83350 ±7844) copies/μg total RNA and (84.20 ±3.78)% at accelerated phase, (79112 ±7956) copies/μg total RNA and (80.15±4.16)% at blast crisis. Bcr-abl gene expression was correlated well with the clinic stages.
结果 CML病人的bcr-abl基因和bcr-abl/abl比率在慢性期分别为(11542±5106)拷贝/μg总RNA和(10.58±5.12)%;加速期分别为(83350±7844)拷贝/μg总RNA和(84.20±3.78)%;急变期分别为(79112±7956)拷贝/μg总RNA和(80.15±4.16)%。bcr-abl基因表达水平与CML不同临床病期密切相关。
The inter-assay comparison were1.14% and 1.01% of CT, 18.89% and 12.72% of the respective concentration. The median value of bcr-abl and bcr-abl/abl ratio were (11542±5106) copies/ug total RNA and (10.58±5.12)% at chronic phase, (83350±7844) copies/ug total RNA and (84.20±3.78)% at accelerated phase, (79112±7956) copies/ug total RNA and (80.15±4.16)% at blast crisis.
应用RQ-PCR检测慢性期CML病人的bcr-abl和bcr-abl/abl比率分别为(11542±5106)拷贝/μg总RNA和(10.58±5.12)%,加速划分别为(83350±7844)拷贝/μg总RNA和(84.20±3.78)%,急变期分别为(79112±7956)拷贝/μg总RNA和(80.15±4.16)%。
Using tagged forms of c-Abl, the present studies demonstrate that c-Abl forms homodimers in cells.
目前研究证明:应用标记的c-Abl发现其在细胞内可以相互形成同源二聚体,并且一分子c-Abl的N末端区域与相应的另一分子的C末端相互作用形成二聚体。
You will also hear your own mistak and be abl to improv them.
还可以听到自己的错误,从而可以改正。